Evidence map›Paper›PMID 36053353›Full record

ArticleClinical oral investigations2022

Comparison of EASYDO ACTIVATOR, passive ultrasonic, and needle irrigation techniques on the treatment of apical periodontitis: a study in rats.

Qin Ye, Yao Feng, Ya-Qiong Zhao, Li Tan, Jing Hu, Shao-Hui Zhang, Jie Zhao, Ying-Hui Zhou, Yue Guo, Yun-Zhi Feng

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Qin Ye *Department of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Yao Feng *Department of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Ya-Qiong ZhaoDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Li Tan *Department of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Jing HuDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Shao-Hui ZhangDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Jie ZhaoDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Ying-Hui ZhouDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Yue GuoDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. guoyue@csu.edu.cn.
Yun-Zhi FengDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. fengyunzhi001@csu.edu.cn.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

Fundamental Research Funds for Central Universities of the Central South University 2014-ZDYZ-1-16Fundamental Research Funds for Central Universities of the Central South University 2020jy165-3Hunan Provincial Science and Technology Department 2017WK2041Hunan Provincial Science and Technology Department 2018SK52511National Natural Science Foundation of China 81773339National Natural Science Foundation of China 81800788Research Project on Postgraduate Education and Teaching Reform of Central South University 2021 NO.61Scientific Research Project of Hunan Provincial Health Commission 202208043514
6 · The paper itself

Abstract

objectivesTo evaluate the long-term therapeutic effect of EASYDO ACTIVATOR, passive ultrasonic irrigation, and needle irrigation in experimental apical periodontitis in rats. MATERIALS AND

methodsSprague-Dawley male rats were used to produce periapical lesions. The pulp chambers of the bilaterally first mandibular molars were exposed and left open for 21 days. The rats were divided into four groups according to different irrigation protocols. Seven days after irrigation, the mandibles were removed for micro-CT, histological, and immunohistochemical analysis. Serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were assessed by enzyme-linked immunosorbent assays (ELISA). Statistical data were analyzed by one-way analysis of variance (ANOVA) with LSD tests.

resultsThe passive ultrasonic irrigation and EASYDO ACTIVATOR groups had the smallest apical lesions compared to the other groups (P < 0.05), while the needle irrigation group had smaller lesions than the control group (P < 0.05). The EASYDO ACTIVATOR group had less inflammation infiltration compared to the control and needle irrigation groups (P < 0.05). The control and needle irrigation groups had more TNF-α expression compared to the passive ultrasonic irrigation and EASYDO ACTIVATOR groups (P < 0.05). The lowest IL-6 expression was observed in the EASYDO ACTIVATOR group. The EASYDO ACTIVATOR group had the lowest serum level of TNF-α than other groups (P < 0.05). IL-6 expression was significantly lower in the EASYDO ACTIVATOR group in comparison with the control and needle irrigation groups (P < 0.05).

conclusionsEASYDO ACTIVATOR can significantly reduce the apical lesions and decrease the inflammatory response around the periapical area. CLINICAL RELEVANCE: EASYDO ACTIVATOR is recommended for clinical application.

Indexed as

Periapical PeriodontitisUltrasonicsAnimalsDental Pulp CavityInterleukin-6MaleRatsRats, Sprague-DawleyRoot Canal IrrigantsRoot Canal PreparationTherapeutic IrrigationTumor Necrosis Factor-alphaInterleukin-6Root Canal IrrigantsTumor Necrosis Factor-alphaApical periodontitisEASYDO ACTIVATORIL-6Needle irrigationPassive ultrasonic irrigationTNF-α

Identifiers

PMID36053353
PMCPMC9708796
OpenAlexW4294266893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.