Evidence map›Paper›PMID 36053212›Full record

ArticleACS sensors2022

Sensors in a Flash! Oxygen Nanosensors for Microbial Metabolic Monitoring Synthesized by Flash Nanoprecipitation.

Tony Tien, Samuel C Saccomano, Pilar A Martin, Madeleine S Armstrong, Robert K Prud'homme, Kevin J Cash

Abstract read
In one paragraph

Article in ACS sensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tony TienChemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, United States.ORCID 0000-0002-0386-0773
Samuel C SaccomanoChemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, United States.ORCID 0000-0001-9105-2663
Pilar A MartinChemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, United States.ORCID 0000-0001-8439-6572
Madeleine S ArmstrongChemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-7261-7742
Robert K Prud'hommeChemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-2858-0097
Kevin J CashChemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, United States.ORCID 0000-0002-9748-2530

Funding

Nanosensors to study invertebrate functional hypoxia and electrolyte regulationR15GM140443 · NIGMS · COLORADO SCHOOL OF MINES · PI CASH, KEVIN JOSEPH · 2020 to 2020
$419k
NIGMS NIH HHS R15 GM140443
6 · The paper itself

Abstract

Flash nanoprecipitation (FNP) is an efficient and scalable nanoparticle synthesis method that has not previously been applied to nanosensor fabrication. Current nanosensor fabrication methods have traditionally exhibited poor replicability and consistency resulting in high batch-to-batch variability, highlighting the need for a more tunable and efficient method such as FNP. We used FNP to fabricate nanosensors to sense oxygen based on an oxygen-sensitive dye and a reference dye, as a tool for measuring microbial metabolism. We used fluorescence spectroscopy to optimize nanosensor formulations, calibrate the nanosensors for oxygen concentration determination, and measure oxygen concentrations through oxygen-sensitive dye luminescence. FNP provides an effective platform for making sensors capable of responding to oxygen concentration in gas-bubbled solutions as well as in microbial environments. The environments we tested the sensors in are

Indexed as

NanoparticlesOxygenLuminescenceSpectrometry, FluorescenceOxygenflash nanoprecipitationFNPmetabolismNanoparticle fabricationnanosensorsoxygen

Identifiers

PMID36053212
PMCPMC9513798

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.