Evidence map›Paper›PMID 36053093›Full record

ArticleWorld journal for pediatric & congenital heart surgery2022

Novel Insights into the Etiology, Genetics, and Embryology of Hypoplastic Left Heart Syndrome.

George C Gabriel, Hisato Yagi, Xinxiu Xu, Cecilia W Lo

Open access · greenAbstract read
In one paragraph

Article in World journal for pediatric & congenital heart surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

George C GabrielDepartment of Developmental Biology, 6614University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hisato YagiDepartment of Developmental Biology, 6614University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0003-1460-4043
Xinxiu XuDepartment of Developmental Biology, 6614University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0003-3867-5030
Cecilia W LoDepartment of Developmental Biology, 6614University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0003-4314-3434
University of Pittsburgh · US

Funding

Modeling the genetic basis for human congenital heart disease in miceU01HL098180 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2009 to 2014
$8.5M
Cellular Approaches to Tissue Engineering/RegenerationT32EB001026 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W, MONGA, SATDARSHAN SINGH · 2003 to 2024
$5.5M
Modeling the complex genetics of congenital heart disease in miceR01HL132024 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2016 to 2019
$3.4M
Assaying Heterotaxy Patient Genes in Cilia Motility and Left-Right PatterningR01GM104412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHENNUBHOTLA, SRINIVAS CHAKRA, LO, CECILIA W. · 2014 to 2017
$2.4M
Confocal enhanced episcopic fluorescent image capture (EFIC)S10OD010340 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2012 to 2012
$368k
Brain Abnormalities and Neurobehavioral Deficits in Hypoplastic Left Heart SyndromeF30HD097967 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GABRIEL, GEORGE CHRISTOPHER · 2019 to 2023
$238k
NHLBI NIH HHS R01 HL132024NHLBI NIH HHS U01 HL098180NIBIB NIH HHS T32 EB001026NICHD NIH HHS F30 HD097967NIGMS NIH HHS R01 GM104412NIH HHS S10 OD010340
6 · The paper itself

Abstract

Hypoplastic left heart syndrome (HLHS) is a relatively rare severe congenital heart defect (CHD) closely linked to other left ventricular outflow tract (LVOT) lesions including bicuspid aortic valve (BAV), one of the most common heart defects. While HLHS, BAV, and other LVOT lesions have a strong genetic underpinning, their genetic etiology remains poorly understood. Findings from a large-scale mouse mutagenesis screen showed HLHS has a multigenic etiology and is genetically heterogenous, explaining difficulties in identifying the genetic causes of HLHS. In

Indexed as

Bicuspid Aortic Valve DiseaseHeart Defects, CongenitalHypoplastic Left Heart SyndromeAnimalsAortic ValveHumansMiceMutationanimal modelbicuspid aortic valvechromatin modifiercirculatory hemodynamicscongenital heart diseasegeneticshypoplastic left heart syndrome

Identifiers

PMID36053093
PMCPMC10010598
OpenAlexW4294281602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.