Evidence map›Paper›PMID 36052742›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy.

Wataru Katagiri, Shinya Yokomizo, Takanobu Ishizuka, Keiko Yamashita, Timo Kopp, Malte Roessing, Akiko Sato, Taizo Iwasaki, Hideki Sato, Takeshi Fukuda and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Light Metabolically Reprograms CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Photobiomodulation and nitric oxide signaling.Nitric oxide : biology and chemistry · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 3 countries.

Wataru KatagiriDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Shinya YokomizoDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Takanobu IshizukaBioresearch Center, Terumo Corporation, Ashigarakami-gun, Japan.
Keiko YamashitaCorporate R&D Center, Terumo Corporation, Ashigarakami-gun, Japan.
Timo KoppInterfaculty Institute of Biochemistry (IFIB), University of Tübingen, Tübingen, Germany.
Malte RoessingInterfaculty Institute of Biochemistry (IFIB), University of Tübingen, Tübingen, Germany.
Akiko SatoBioresearch Center, Terumo Corporation, Ashigarakami-gun, Japan.
Taizo IwasakiBioresearch Center, Terumo Corporation, Ashigarakami-gun, Japan.
Hideki SatoBioresearch Center, Terumo Corporation, Ashigarakami-gun, Japan.
Takeshi FukudaDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Hailey MonacoDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Sophia ManganielloDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Shinsuke NomuraDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Mei Rosa NgEdwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Susanne FeilInterfaculty Institute of Biochemistry (IFIB), University of Tübingen, Tübingen, Germany.
Emiyu OgawaSchool of Allied Health Science, Kitasato University, Sagamihara, Japan.
Dai FukumuraEdwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9505-4444
Dmitriy N AtochinDepartment of Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Hak Soo ChoiDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Satoshi KashiwagiDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0001-8910-3257
Gordon Center for Medical Imaging · USTerumo (Japan) · JPMassachusetts General Hospital · USUniversity of Tübingen · DEKeio University · JPKitasato University · JP

Funding

cGMP-dependent protein kinase I as a new target against strokeR01NS096237 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ATOCHIN, DMITRIY · 2016 to 2020
$1.8M
Near-infrared laser to replace chemical vaccine adjuvantR01AI105131 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI KASHIWAGI, SATOSHI · 2013 to 2016
$1.7M
Laser-based non-invasive immunotherapy for food allergyR21AI144103 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI KASHIWAGI, SATOSHI · 2019 to 2020
$433k
NIAID NIH HHS R01 AI105131NIAID NIH HHS R21 AI144103NINDS NIH HHS R01 NS096237
6 · The paper itself

Abstract

Immunotherapy, including immune checkpoint inhibitors, has revolutionized cancer treatment, but only a minor fraction of patients shows durable responses. A new approach to overcome this limitation is yet to be identified. Recently, we have shown that photobiomodulation (PBM) with near-infrared (NIR) light in the NIR-II window reduces oxidative stress and supports the proliferation of CD8

Indexed as

CD8-Positive T-LymphocytesNeoplasmsAnimalsImmunotherapyLasersMiceOxidation-Reductionimmunotherapymultispectral near-infrared II laserphotobiomodulationT cell exhaustiontumor microenvironment

Identifiers

PMID36052742
PMCPMC9574655
OpenAlexW4294218890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.