Evidence map›Paper›PMID 36052690›Full record

Observational studyCirculation research2022

Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts.

Jie Hu, Jie Yao, Shuliang Deng, Raji Balasubramanian, Monik C Jiménez, Jun Li, Xiuqing Guo, Daniel E Cruz, Yan Gao, Tianyi Huang and 20 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Review
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  7. Reproducibility of Plasma Metabolome over 1 Year in a Population-Based Cohort of Black Breast Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Metabolomic heterogeneity of ageing with ethnic diversity: a step closer to healthy ageing.Metabolomics : Official journal of the Metabolomic Society · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 15 institutions in 3 countries.

Jie HuDivision of Women's Health (J.H., M.C.J., K.M.R.), Harvard Medical School, Boston, MA.ORCID 0000-0001-8282-4895
Jie YaoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., J.I.R.).ORCID 0000-0002-8822-0651
Shuliang DengDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.D., D.E.C., R.E.G.).
Raji BalasubramanianDepartment of Biostatistics and Epidemiology, University of Massachusetts - Amherst (R.B.).ORCID 0000-0002-1488-1692
Monik C JiménezDivision of Women's Health (J.H., M.C.J., K.M.R.), Harvard Medical School, Boston, MA.
Jun LiDivision of Preventive Medicine (J.L., N.P.P.), Harvard Medical School, Boston, MA.ORCID 0000-0003-3519-8638
Xiuqing GuoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., J.I.R.).ORCID 0000-0002-5264-5068
Daniel E CruzDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.D., D.E.C., R.E.G.).
Yan GaoDepartment of Medicine, University of Mississippi Medical Center, Jackson (Y.G.).
Tianyi HuangChanning Division of Network Medicine, Department of Medicine (T.H., O.A.Z., Q.S., E.B.R., A.H.E.), Harvard Medical School, Boston, MA.ORCID 0000-0001-8420-9167
Oana A ZeleznikChanning Division of Network Medicine, Department of Medicine (T.H., O.A.Z., Q.S., E.B.R., A.H.E.), Harvard Medical School, Boston, MA.ORCID 0000-0002-8705-1163
Debby NgoBrigham and Women's Hospital and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center (D.N.), Harvard Medical School, Boston, MA.ORCID 0000-0003-2681-3475
Simin LiuDepartment of Epidemiology, Brown University School of Public Health, Providence, RI (S.L.).ORCID 0000-0003-2098-3844
Milagros C RosalDivision of Preventive and Behavioral Medicine, Department of Population and Quantitative Sciences, University of Massachusetts Medical School, Worcester (M.C.R.).
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura University, Saudi Arabia (R.N.).
Nina P PaynterDivision of Preventive Medicine (J.L., N.P.P.), Harvard Medical School, Boston, MA.
Christine M AlbertDepartment of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (C.M.A.).ORCID 0000-0002-2081-1121
Russell P TracyDepartment of Pathology and Laboratory Medicine (R.P.T., P.D.), Larner College of Medicine, University of Vermont, Burlington.ORCID 0000-0002-0080-2420
Peter DurdaDepartment of Pathology and Laboratory Medicine (R.P.T., P.D.), Larner College of Medicine, University of Vermont, Burlington.ORCID 0000-0003-4000-2943
Yongmei LiuDivisions of Cardiology and Neurology, Department of Medicine, Duke University Medical Center, Durham, NC (Y.L.).
Kent D TaylorDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., J.I.R.).ORCID 0000-0002-2756-4370
W Craig JohnsonDepartment of Biostatistics, University of Washington, Seattle (W.C.J.).ORCID 0000-0002-3161-3753
Qi SunChanning Division of Network Medicine, Department of Medicine (T.H., O.A.Z., Q.S., E.B.R., A.H.E.), Harvard Medical School, Boston, MA.ORCID 0000-0002-8480-1563
Eric B RimmChanning Division of Network Medicine, Department of Medicine (T.H., O.A.Z., Q.S., E.B.R., A.H.E.), Harvard Medical School, Boston, MA.
A Heather EliassenChanning Division of Network Medicine, Department of Medicine (T.H., O.A.Z., Q.S., E.B.R., A.H.E.), Harvard Medical School, Boston, MA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville (S.S.R.).ORCID 0000-0003-3872-7793
Jerome I RotterDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., J.I.R.).ORCID 0000-0001-7191-1723
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.D., D.E.C., R.E.G.).ORCID 0000-0002-6767-7687
Clary B ClishBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge (R.E.G., C.B.C.).ORCID 0000-0001-8259-9245
Kathryn M RexrodeDivision of Women's Health (J.H., M.C.J., K.M.R.), Harvard Medical School, Boston, MA.ORCID 0000-0003-3387-8429
Harvard University · USUCLA Medical Center · USBeth Israel Deaconess Medical Center · USBroad Institute · USUniversity of Vermont · USBrigham and Women's Hospital · USBrown University · USCedars-Sinai Smidt Heart Institute · USDuke University · USOffice of Public Health Genomics · USUmm al-Qura University · SAUniversity of Massachusetts Amherst · USUniversity of Massachusetts Chan Medical School · USUniversity of Mississippi Medical Center · USUniversity of Washington · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
The role of stroke risk factors in the prevalence of stroke symptoms among Hispanic/Latinx AdultsR03HL160625 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI JIMENEZ, MONIK CARMEN · 2022 to 2023
$179k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS HHSN268201300008CNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS R03 HL160625
6 · The paper itself

Abstract

backgroundRacial differences in metabolomic profiles may reflect underlying differences in social determinants of health by self-reported race and may be related to racial disparities in coronary heart disease (CHD) among women in the United States. However, the magnitude of differences in metabolomic profiles between Black and White women in the United States has not been well-described. It also remains unknown whether such differences are related to differences in CHD risk.

methodsPlasma metabolomic profiles were analyzed using liquid chromatography-tandem mass spectrometry in the WHI-OS (Women's Health Initiative-Observational Study; 138 Black and 696 White women), WHI-HT trials (WHI-Hormone Therapy; 156 Black and 1138 White women), MESA (Multi-Ethnic Study of Atherosclerosis; 114 Black and 219 White women), JHS (Jackson Heart Study; 1465 Black women with 107 incident CHD cases), and NHS (Nurses' Health Study; 2506 White women with 136 incident CHD cases). First, linear regression models were used to estimate associations between self-reported race and 472 metabolites in WHI-OS (discovery); findings were replicated in WHI-HT and validated in MESA. Second, we used elastic net regression to construct a racial difference metabolomic pattern (RDMP) representing differences in the metabolomic patterns between Black and White women in the WHI-OS; the RDMP was validated in the WHI-HT and MESA. Third, using conditional logistic regressions in the WHI (717 CHD cases and 719 matched controls), we examined associations of metabolites with large differences in levels by race and the RDMP with risk of CHD, and the results were replicated in Black women from the JHS and White women from the NHS.

resultsOf the 472 tested metabolites, levels of 259 (54.9%) metabolites, mostly lipid metabolites and amino acids, significantly differed between Black and White women in both WHI-OS and WHI-HT after adjusting for baseline characteristics, socioeconomic status, lifestyle factors, baseline health conditions, and medication use (false discovery rate <0.05); similar trends were observed in MESA. The RDMP, composed of 152 metabolites, was identified in the WHI-OS and showed significantly different distributions between Black and White women in the WHI-HT and MESA. Higher RDMP quartiles were associated with an increased risk of incident CHD (odds ratio=1.51 [0.97-2.37] for the highest quartile comparing to the lowest;

conclusionsMetabolomic profiles significantly and substantially differ between Black and White women and may be associated with CHD risk and racial disparities in US women.

Indexed as

Coronary DiseaseAmino AcidsFemaleHormonesHumansLipidsRisk FactorsUnited StatesAmino AcidsHormonesLipidshealth status disparitiesheart diseasesmetabolomicsplasmaracewomen

Identifiers

PMID36052690
PMCPMC9473718
OpenAlexW4294218879

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.