Evidence map›Paper›PMID 36052397›Full record

ArticleTherapeutic advances in drug safety2022

Prevalence and global trends of polypharmacy among people living with HIV: a systematic review and meta-analysis.

Mohammed I Danjuma, Oyelola A Adegboye, Ahmed Aboughalia, Nada Soliman, Ruba Almishal, Haseeb Abdul, Mohamad Faisal Hamad Mohamed, Mohamed Nabil Elshafie, Abdulatif AlKhal, Abdelnaser Elzouki and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in drug safety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Mohammed I DanjumaDepartment of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar College of Medicine, QU Health, Qatar University, Doha, Qatar.ORCID https://orcid.org/0000-0003-2198-5278
Oyelola A AdegboyeEvolution Equations Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Ahmed AboughaliaCollege of Medicine, QU Health, Qatar University, Doha, Qatar.
Nada SolimanCollege of Medicine, QU Health, Qatar University, Doha, Qatar.
Ruba AlmishalCollege of Medicine, QU Health, Qatar University, Doha, Qatar.
Haseeb AbdulCollege of Medicine, QU Health, Qatar University, Doha, Qatar.
Mohamad Faisal Hamad MohamedDepartment of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Mohamed Nabil ElshafieDepartment of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Abdulatif AlKhalCollege of Medicine, QU Health, Qatar University, Doha, Qatar.
Abdelnaser ElzoukiDepartment of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Arwa Al-SaudDepartment of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Mas ChapondaDepartment of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Mubarak Arriyo BidmosCollege of Medicine, QU Health, Qatar University, Doha, Qatar.
Hamad General Hospital · QAQatar University · QAHamad Medical Corporation · QATon Duc Thang University · VNUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There has been a rising prevalence of polypharmacy among people living with HIV (PLWH). Uncertainty however remains regarding the exact estimates of polypharmacy among these cohorts of patients. Methods: We conducted a systematic search of PubMed; EMBASE, CROI, Cochrane Database of Systematic Reviews; Science Citation Index and Database of Abstracts of Reviews of Effects for studies between 1 January 2000 and 30 June 2021 that reported on the prevalence of polypharmacy (ingestion of > 5 non-ART medications) among PLWH on antiretroviral therapy regimen (ART). Prevalence of polypharmacy among HIV-positive patients on ART with Clopper-Pearson 95% confidence intervals were presented. The heterogeneity between studies was evaluated using Results: One hundred ninety-seven studies were initially identified, 23 met the inclusion criteria enrolling 55,988 PLWH, of which 76.7% [95% confidence interval (CI): 76.4-77.1] were male. The overall pooled prevalence of polypharmacy among PLWH was 33% (95% CI: 25-42%) ( Conclusion: The pooled prevalence estimates from this synthesis established that polypharmacy is a significant and rising problem among PLWH. The exact interventions that are likely to significantly mitigate its effect remain uncertain and will need exploration by future prospective and systematic studies. Registration: Plain Language Summary:

Indexed as

ARTHIVPLWHpolypharmacyprevalence

Identifiers

PMID36052397
PMCPMC9425890
OpenAlexW4292737051

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.