ReviewFrontiers in pediatrics2022
The heart in congenital diaphragmatic hernia: Knowns, unknowns, and future priorities.
Review in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Pulse pressure as an early mortality predictor in neonates with congenital diaphragmatic hernia on veno-arterial ECMO.Pediatric surgery international · 2026Article
- Born under pressure: cardiac adaptation in congenital diaphragmatic hernia.Pediatric research · 2026Article
- Diastolic function in newborn infants: understanding pathophysiology, diagnosis and clinical relevance.Pediatric research · 2026Review
- Echocardiographic predictors of adverse outcomes in infants with congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Pulmonary T2* quantification of fetal lung status in congenital diaphragmatic hernia: future alternative to ultrasound?Pediatric research · 2026Article
- Early post-operative hemodynamic recovery in infants with congenital diaphragmatic hernia.European journal of pediatrics · 2026Article
- Echocardiographic assessment of left ventricular diastolic dysfunction in congenital diaphragmatic hernia.Pediatric research · 2026Article
- An overview of the placenta's role in the development of congenital diaphragmatic hernia.Frontiers in pediatrics · 2026Review
- Early postnatal echocardiographic characteristics impact survival and extracorporeal life support in congenital diaphragmatic hernia.Pediatric research · 2026Article
- Early left ventricular diastolic function and disease severity in congenital diaphragmatic hernia.Pediatric research · 2025Article
- Utility of urinary NT-proBNP in congenital diaphragmatic hernia: a prospective pilot study.Pediatric research · 2025Observational
- Safety and Feasibility of Early Targeted Neonatal Echocardiography and a Focused Assessment Protocol in Neonates With Congenital Diaphragmatic Hernia.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Hemodynamic precision to guide surgical timing for neonates with congenital diaphragmatic hernia: a narrative review.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Cardiac function in children with congenital diaphragmatic hernia: cardiac strain at birth and at 2-5 weeks of age.Frontiers in pediatrics · 2025Article
- Implementation of the Oxygen Saturation Index as a Predictor of Outcome in Prenatally Diagnosed CDH Neonates in the First 24 Hours of Life.Pediatric pulmonology · 2025Article
- Patterns of Co-Occurring Birth Defects in Chinese Infants With Congenital Diaphragmatic Hernia: A National Hospital-Based Surveillance Study.Birth defects research · 2025Article
- Congenital heart disease and arrhythmia disorders in newborns with congenital diaphragmatic hernia: a 23-year experience at a UK university pediatric surgical centre.Pediatric surgery international · 2024Article
- Applications of Point-of-Care-Ultrasound in Neonatology: A Systematic Review of the Literature.Life (Basel, Switzerland) · 2024Review
- Major surgical conditions of childhood and their lifelong implications: comprehensive review.BJS open · 2024Review
- The role of point-of-care ultrasound in the management of neonates with congenital diaphragmatic hernia.Pediatric research · 2024Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing recognition that the heart is a key contributor to the pathophysiology of congenital diaphragmatic hernia (CDH), in conjunction with developmental abnormalities of the lung and pulmonary vasculature. Investigations to date have demonstrated altered fetal cardiac morphology, notably relative hypoplasia of the fetal left heart, as well as early postnatal right and left ventricular dysfunction which appears to be independently associated with adverse outcomes. However, many more unknowns remain, not least an understanding of the genetic and cellular basis for cardiac dysplasia and dysfunction in CDH, the relationship between fetal, postnatal and long-term cardiac function, and the impact on other parts of the body especially the developing brain. Consensus on how to measure and classify cardiac function and pulmonary hypertension in CDH is also required, potentially using both non-invasive imaging and biomarkers. This may allow routine assessment of the relative contribution of cardiac dysfunction to individual patient pathophysiological phenotype and enable better, individualized therapeutic strategies incorporating targeted use of fetal therapies, cardiac pharmacotherapies, and extra-corporeal membrane oxygenation (ECMO). Collaborative, multi-model approaches are now required to explore these unknowns and fully appreciate the role of the heart in CDH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.