ArticleFrontiers in digital health2022
Meaningful engagement: A crossfunctional framework for digital therapeutics.
Article in Frontiers in digital health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Trial
- Real-time cognitive performance metrics derived from a digital therapeutic for inattention predict ADHD-related clinical outcomes: Replication across three independent trials of AKL-T01.Translational psychiatry · 2024Trial
- Impact of Different Onboarding Strategies on Low Adoption and Engagement With a Self-Monitoring and Management App for Chronic Musculoskeletal Pain: Prospective Study.JMIR mHealth and uHealth · 2026Article
- Mechanisms of action for digital therapeutics.NPJ digital medicine · 2026Review
- Strategies to Increase Patients' Adherence to Digital Therapeutics for Musculoskeletal Diseases: A Narrative Review.Yonsei medical journal · 2026Review
- The Heartline Experience: Achieving Long-Term Participant Engagement in Digital Health Technology Trials.JACC. Advances · 2025Article
- Designing a Visual Analytics Tool to Support Data Analysis Tasks of Digital Mental Health Interventions: Case Study.JMIR human factors · 2025Article
- Digital Therapeutics for Cognitive Impairment: Exploring Innovations, Challenges, and Future Prospects.Journal of medical Internet research · 2025Article
- Assessment of digital therapeutics in decentralized clinical trials: A scoping review.PLOS digital health · 2025Article
- Pilot Study of Factors Influencing Engagement with an mHealth Intervention Among Teens with Eating Disorder Symptoms.Journal of technology in behavioral science · 2025Article
- Achieving clinically meaningful outcomes in digital health: a six-step, cyclical precision engagement framework (ENGAGE).Frontiers in digital health · 2025Article
- Assessing the Efficacy and Safety of a Digital Therapeutic for Symptoms of Depression in Adolescents: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Mapping Factors That Affect the Uptake of Digital Therapeutics Within Health Systems: Scoping Review.Journal of medical Internet research · 2023Article
- Leveraging machine learning to examine engagement with a digital therapeutic.Frontiers in digital health · 2023Article
- A CBT-based mobile intervention as an adjunct treatment for adolescents with symptoms of depression: a virtual randomized controlled feasibility trial.Frontiers in digital health · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Digital mental health interventions, or digital therapeutics, have the potential to transform the field of mental health. They provide the opportunity for increased accessibility, reduced stigma, and daily integration with patient's lives. However, as the burgeoning field continues to expand, there is a growing concern regarding the level and type of engagement users have with these technologies. Unlike many traditional technology products that have optimized their user experience to maximize the amount of time users spend within the product, such engagement within a digital therapeutic is not sufficient if users are not experiencing an improvement in clinical outcomes. In fact, a primary challenge within digital therapeutics is user engagement. Digital therapeutics are only effective if users sufficiently engage with them and, we argue, only if users meaningfully engage with the product. Therefore, we propose a 4-step framework to assess meaningful engagement within digital therapeutics: (1) Define the measure of value (2) Operationalize meaningful engagement for your digital therapeutic (3) Implement solutions to increase meaningful engagement (4) Iteratively evaluate the solution's impact on meaningful engagement and clinical outcomes. We provide recommendations to the common challenges associated with each step. We specifically emphasize a cross-functional approach to assessing meaningful engagement and use an adolescent-focused example throughout to further highlight developmental considerations one should consider depending on their target users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.