Evidence map›Paper›PMID 36052070›Full record

ArticleFrontiers in immunology2022

Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells.

Philipp Burt, Michael Peine, Caroline Peine, Zuzanna Borek, Sebastian Serve, Michael Floßdorf, Ahmed N Hegazy, Thomas Höfer, Max Löhning, Kevin Thurley

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  5. Article
  6. Article
  7. Article
  8. Article
  9. A review of CD4Veterinary immunology and immunopathology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Hybrid lineages of CD4Frontiers in immunology · 2024
    Review
  14. Article
  15. Article
  16. CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels.Journal of cancer research and clinical oncology · 2023
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Philipp BurtSystems Biology of Inflammation, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany.
Michael PeinePitzer Laboratory of Osteoarthritis Research, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany.
Caroline PeinePitzer Laboratory of Osteoarthritis Research, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany.
Zuzanna BorekSystems Biology of Inflammation, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany.
Sebastian ServeSystems Biology of Inflammation, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany.
Michael FloßdorfDivision of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ahmed N HegazyDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin, Berlin, Germany.
Thomas HöferDivision of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Max LöhningPitzer Laboratory of Osteoarthritis Research, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany.
Kevin ThurleySystems Biology of Inflammation, German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEGerman Cancer Research Center · DEGerman Rheumatism Research Centre · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th-cell lineages, hybrid phenotypes such as Th1/2 cells arise

Indexed as

Th1 CellsTh2 CellsCell DifferentiationHybrid CellsLymphocyte Activationcell differentiationlineage commitmentregression analysisT helper celltime-course transcriptomics

Identifiers

PMID36052070
PMCPMC9424495
OpenAlexW4291914417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.