ArticleFrontiers in public health2022
The Global Burden of Diseases attributed to high low-density lipoprotein cholesterol from 1990 to 2019.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed.
- Prevalence of Dyslipidemia and Associated Factors Among Adult Outpatients at Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study.Health science reports · 2026Article
- Ischemic Heart Disease in the Middle East and North Africa, 1990-2021: An Integrated Analysis of Temporal Trends, Country-Level Variation, SDI Patterns, and Risk Factors.Health science reports · 2026Article
- Total cholesterol and the associated factors among adults aged 18-69 years in Uganda: analysis of the 2023 national population-based non-communicable disease survey data.BMC public health · 2026Article
- Extraction and Purification of Polysaccharides from ThermotolerantMarine drugs · 2026Article
- The Complex Relationship Between HDL/LDL Cholesterol, Stroke and Cardiovascular Disease.Healthcare (Basel, Switzerland) · 2026Article
- Upper Arm to Upper Leg Length Ratio and Dyslipidemia: A Novel Application of a Fixed Skeletal Proportion Metric in a Nationally Representative U.S. Sample.International journal of environmental research and public health · 2026Article
- Cost-Utility Analysis of High-Intensity Statins; Atorvastatin 40 and 80 mg versus Rosuvastatin 20 mg from Egyptian Public Payer's Perspective: A Markov Model.International journal of preventive medicine · 2026Article
- Use of traditional medicine for hypertension, diabetes and hypercholesterolaemia measured in 71 surveys.Bulletin of the World Health Organization · 2025Article
- Efficacy and Safety of Evolocumab in Improving Low-Density Lipoprotein Cholesterol (LDL-C) Levels in a Japanese Population - Systematic Review and Meta-Analysis.Circulation reports · 2025Article
- Association between volatile organic compounds in urine and dyslipidemia: findings based on analysis of NHANES data.Lipids in health and disease · 2025Article
- Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework.EBioMedicine · 2025Review
- The Rising Global Burden of MASLD and Other Metabolic Diseases (2000-2021).United European gastroenterology journal · 2025Article
- Reshaping Dyslipidaemia Treatment with Bempedoic Acid-A Narrative Review.Biomedicines · 2025Review
- Comparing burden of ischemic stroke caused by high low-density lipoprotein cholesterol in global and China: trends and projections.Frontiers in neurology · 2025Article
- Global Guidance for Dyslipidaemia Management in Adults: A Scoping Review.Global heart · 2025Article
- Real-world data lipid profiles in one million colombian adults: The LiPAC million person study.Atherosclerosis plus · 2024Article
- Association between low-density lipoprotein cholesterol levels and all-cause mortality in patients with coronary artery disease: a real-world analysis using data from an international network.Scientific reports · 2024Article
- Article
- Temporal trends of the burden of ischemic stroke attributable to high low-density lipoprotein cholesterol in China from 1999 to 2019.BMC public health · 2024Article
- Hypercholesterolemia and the Increased Risk of Vascular Dementia: a Cholesterol Perspective.Current atherosclerosis reports · 2024Review
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Abstract
Background: To demonstrate the real-word situation of burdens that are attributed to the risk factor of high low-density lipoprotein cholesterol (LDL-C) at the global, regional, national levels, among different age groups and between genders. Methods: We analyzed data from the Global Burden of Disease study 2019 related to global deaths, disability-adjusted life years (DALYs), summary exposure value (SEV), average annual percentage change (AAPC), and observed to expected ratios (O/E ratios) attributable to high LDL-C from 1990 to 2019. Results: Globally, in 2019, the total numbers of deaths and DALYs attributed to high LDL cholesterol were 1.47 and 1.41 times higher than that in 1990. The age-standardized deaths and DALYs rate was 1.45 and 1.70 times in males compared to females, while the age-standardized SEVs rate was 1.10 times in females compared to males. The deaths, DALYs, and SEV rates increased with age. In 2019, the highest age-standardized rates of both deaths and DALYs occurred in Eastern Europe while the lowest occurred in high-income Asia Pacific. High-income North America experienced a dramatic reduction of risk related to high LDL-C. Correlation analysis identified that the age-standardized SEV rate was positively correlated with Socio-demographic Index (SDI; Conclusion: High LDL-C contributed considerably to health burden worldwide. Males suffered worse health outcomes attributed to high LDL-C when compared to females. The burden attributed to high LDL-C increased with age. Lower SDI regions and countries experienced more health problem challenges attributed to high LDL-C as the result of social development and this should be reflected in policymaking.
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