SynthesisFrontiers in physiology2022
Optimal target blood pressure in critically ill adult patients with vasodilatory shock: A systematic review and meta-analysis.
Synthesis in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Mortality effect of higher versus lower blood pressure targets in vasodilatory shock: an updated systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial.Intensive care medicine · 2025Trial
- Resuscitation Targets, Fluids, and Vasoactives in Septic Shock.Clinics in chest medicine · 2026Review
- Higher Versus Lower Mean Arterial Blood Pressure Targets in Vasodilatory Shock.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Review
- Optimizing Mean Arterial Pressure Targets for Septic Shock Patients With Chronic Hypertension: A Narrative Review.Health science reports · 2025Article
- Excessive vasopressors or excessive hypotension: Searching for the goldilocks zone in mean arterial pressure targets.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Mean arterial pressure in critically ill adults receiving vasopressors: A multicentre, observational study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Low systemic vascular resistance with normal blood pressure: Do we need vasopressors?PloS one · 2025Article
- Acute Kidney Injury in Sepsis.International journal of molecular sciences · 2024Review
- Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of personalized medicine · 2024Review
- Mean arterial pressure and outcomes in critically ill patients: is there a difference between high and low target?Revista da Associacao Medica Brasileira (1992) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the Surviving Sepsis Campaign guidelines recommend an initial target value of 65 mmHg as the mean arterial pressure (MAP) in patients with septic shock, the optimal MAP target for improving outcomes remains controversial. We performed a meta-analysis to evaluate the optimal MAP for patients with vasodilatory shock, which included three randomized controlled trials that recruited 3,357 patients. Between the lower (60-70 mmHg) and higher (>70 mmHg) MAP target groups, there was no significant difference in all-cause mortality (risk ratio [RR], 1.06; 95% confidence intervals [CI], 0.98-1.16) which was similar in patients with chronic hypertension (RR, 1.10; 95% CI, 0.98-1.24) and patients aged ≥65 years (RR, 1.10; 95% CI, 0.99-1.21). No significant difference in adverse events was observed between the different MAP groups (RR, 1.04; 95% CI, 0.87-1.24); however, supraventricular arrhythmia was significantly higher in the higher MAP group (RR, 1.73; 95% CI, 1.15-2.60). Renal replacement therapy was reduced in the higher MAP group of patients with chronic hypertension (RR, 0.83; 95% CI, 0.71-0.98). Though the higher MAP control did not improve the mortality rate, it may be beneficial in reducing renal replacement therapy in patients with chronic hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.