Evidence map›Paper›PMID 36051821›Full record

ArticleAdvanced nanobiomed research2022

CD36-Binding Amphiphilic Nanoparticles for Attenuation of Alpha Synuclein-Induced Microglial Activation.

Nanxia Zhao, Nicola L Francis, Shuang Song, Vladyslav Kholodovych, Hannah R Calvelli, Cody L Hoop, Zhiping P Pang, Jean Baum, Kathryn E Uhrich, Prabhas V Moghe

Open access · goldAbstract read
In one paragraph

Article in Advanced nanobiomed research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Theranostic Nanoparticles for Fluorosensitive Visualization and Inhibition of Amyloid Beta-Induced Neuroinflammation.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nanxia ZhaoDepartment of Chemical and Biochemical Engineering, 98 Brett Rd, Rutgers University, NJ, 08854 USA.
Nicola L FrancisDepartment of Biomedical Engineering, 599 Taylor Rd., Rutgers University, NJ, 08854 USA.
Shuang SongDepartment of Chemistry, 501 Big Springs Rd., University of California, Riverside, CA, 92507 USA.
Vladyslav KholodovychOffice of Advanced Research Computing, 96 Frelinghuysen Road, Rutgers University, NJ, 08854 USA.
Hannah R CalvelliDepartment of Molecular Biology & Biochemistry, 604 Allison Rd, Rutgers University, NJ, 08854 USA.
Cody L HoopDepartment of Chemistry & Chemical Biology, 123 Bevier Rd, Rutgers University, NJ, 08854 USA.
Zhiping P PangDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 604 Allison Rd, Rutgers University, NJ, 08854 USA.
Jean BaumDepartment of Chemistry & Chemical Biology, 123 Bevier Rd, Rutgers University, NJ, 08854 USA.
Kathryn E UhrichDepartment of Chemistry, 501 Big Springs Rd., University of California, Riverside, CA, 92507 USA.
Prabhas V MogheDepartment of Chemical and Biochemical Engineering, 98 Brett Rd, Rutgers University, NJ, 08854 USA.
Rutgers, The State University of New Jersey · USUniversity of California, Riverside · US

Funding

Rutgers Helium Recovery System for High Field NMRR35GM136431 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI BAUM, JEAN S · 2020 to 2024
$3.3M
Microglial-Targeted Nanotherapeutics for Inhibition of Alpha-Synuclein Aggregation and Inflammation in Neurodegenerative DiseasesR21AG060024 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI MOGHE, PRABHAS V, PANG, ZHIPING P. · 2018 to 2019
$435k
Nanofibrous Scaffolds for Transplantation of Human Dopaminergic NeuronsR21NS095082 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI MOGHE, PRABHAS V, PANG, ZHIPING P. · 2015 to 2016
$424k
NIA NIH HHS R21 AG060024NIGMS NIH HHS R35 GM136431NINDS NIH HHS R21 NS095082
6 · The paper itself

Abstract

Neuroinflammation is one of the hallmarks contributing to Parkinson's Disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular alpha synuclein (aSYN) binding to the CD36 receptor. Here, CD36-binding nanoparticles (NPs) containing synthetic tartaric acid-based amphiphilic polymers (AMs) were rationally designed to inhibit this aSYN-CD36 binding.

Indexed as

alpha synucleinCD36microgliananomedicineneuroinflammationParkinson’s Disease

Identifiers

PMID36051821
PMCPMC9426437
OpenAlexW4221066483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.