ReviewSAGE open medicine2022
Global impact and contributing factors in varicose vein disease development.
Review in SAGE open medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Sublingual varices as predictor of factors associated with cardiovascular diseases: A systematic review with meta-analysis.Oral and maxillofacial surgery · 2024Pooled it
- Quality-of-life outcomes after varicose vein surgery: A 12-month prospective study of 605 patients identifying key prognostic factors.Journal of vascular surgery. Venous and lymphatic disorders · 2026Article
- Global trends and collaborative networks in minimally invasive treatments for great saphenous varicose veins: a bibliometric analysis.Journal of cardiothoracic surgery · 2026Article
- Endovenous chemical ablation and trendelenburg's (eCAT) operation for treating great saphenous vein varicosities: a single-arm open-label interventional study.Langenbeck's archives of surgery · 2026Article
- A survey of self-reported varicose veins with prior clinical diagnosis among adults residing in the United Arab Emirates: a cross-sectional study examining associated factors.Frontiers in epidemiology · 2026Article
- Sex differences in 1,114,625 varicose vein surgeries: an 18-year cross-sectional analysis of the Brazilian public health system.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Therapeutic effect ofBioinformation · 2026Article
- Evaluation of the vascular remodeling markers elastin, vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR2), and nitric oxide in patients with varicose veins.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2025Article
- Altered venous flow drives endothelial to mesenchymal transition in varicose veins by suppressing PIEZO1-KLF2 signaling.Cellular and molecular life sciences : CMLS · 2025Article
- Vitamin D alleviates oxidative stress in varicose veins: a pilot study in obese and non-obese patients.Molecular and cellular biochemistry · 2025Article
- Development and validation of a clinical prediction model for Iliac vein compression syndrome in outpatients with varicose veins of the lower extremities.Scientific reports · 2025Article
- Clinical and demographic characteristics of patients undergoing endovenous laser ablation for saphenous vein insufficiency.Journal of family medicine and primary care · 2025Article
- Endothelium Piezo1 deletion alleviates experimental varicose veins by attenuating perivenous inflammation.Molecular and cellular biochemistry · 2025Article
- Association between varicose veins and occurrence of dementia: A nationwide population-based cohort study.PloS one · 2025Article
- Estimation of the inflammatory biomarker IL-6 in blood samples from varicose veins after repeatedFrontiers in medicine · 2025Article
- Risk Factors Associated With Postoperative Complications Following Endovenous Laser Ablation for Varicose Veins.International journal of vascular medicine · 2025Article
- Assessing the quality of ChatGPT's responses to questions related to radiofrequency ablation for varicose veins.Journal of vascular surgery. Venous and lymphatic disorders · 2025Article
- Article
- Association of varicose veins with the risk of heart failure: A nationwide cohort study.PloS one · 2025Article
- Tissue Ablation: Applications and Perspectives.Advanced materials (Deerfield Beach, Fla.) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Varicose veins are convoluted, expanded, and stretched subcutaneous veins of the lower leg and are the most frequently reported medical condition. This condition has a higher prevalence in Western and developed countries. Inadequacy of the valves results in reflux of blood in the veins of the lower leg. The present study aims to describe the epidemiology and contributing factors (risk factors and pathological factors) in the development of varicose veins disease. PubMed/Medline, Science Direct, Google Scholar, SciFinder, Scopus, and Web of Science databases were explored to include potential research and review articles. Finally, 65 articles were considered appropriate to include in the study. Pain, swelling, heaviness, and tingling of the lower limbs are the most common sign and symptoms caused by varicose veins while in some individuals it is asymptomatic. The Prevalence of varicose veins varies geographically. Currently, it is reported that globally about 2%-73% of the population is affected by varicose veins while the prevalence rate in Pakistan is 16%-20%. Different risk factors associated with the advancement of varicose veins are age, gender, occupation, pregnancy, family history, smoking, BMI and obesity, exercise, genetic factor, and current lifestyle. In varicose veins, some contributory elements may also play an important role in the disease development, incorporating constant venous wall aggravation, hereditary variation, and persistent venous hypertension. This condition has now turned into a curable issue that was previously viewed broadly as less important for treatment, determining the individual's satisfaction. Moreover, the mechanisms behind the risk factors involve diet, physical work, and hormonal contribution. These are more likely to be explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.