ArticleWorld journal of psychiatry2022
Clinical characteristics of pediatric patients with treatment-refractory Tourette syndrome: An evidence-based survey in a Chinese population.
Article in World journal of psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Functional connectivity of the precuneus and posterior cingulate cortex moderates the relationship between tic symptoms and premonitory urge in tourette syndrome.European child & adolescent psychiatry · 2025Article
- Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disorders.BMC pediatrics · 2024Article
- Factors linked to prognosis in children with provisional tic disorder: a prospective cohort study.European journal of pediatrics · 2024Article
- Clinical evaluation of premonitory urges in children and adolescents using the Chinese version of Individualized Premonitory Urge for Tics Scale.Frontiers in psychiatry · 2023Article
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Abstract
backgroundTourette syndrome (TS) is a complex neurodevelopmental condition marked by tics, as well as a variety of psychiatric comorbidities, such as obsessive-compulsive disorders (OCDs), attention deficit hyperactivity disorder (ADHD), anxiety, and self-injurious behavior. TS might progress to treatment-refractory Tourette syndrome (TRTS) in some patients. However, there is no confirmed evidence in pediatric patients with TRTS.
aimTo investigate the clinical characteristics of TRTS in a Chinese pediatric sample.
methodsA total of 126 pediatric patients aged 6-12 years with TS were identified, including 64 TRTS and 62 non-TRTS patients. The Yale Global Tic Severity Scale (YGTSS), Premonitory Urge for Tics Scale (PUTS), and Child Behavior Checklist (CBCL) were used to assess these two groups and compared the difference between the TRTS and non-TRTS patients.
resultsWhen compared with the non-TRTS group, we found that the age of onset for TRTS was younger (
conclusionPediatric TRTS might show an earlier age of onset age, longer duration of illness, lower IQ, higher premonitory urge, and higher comorbidities with ADHD-related symptoms and OCD-related symptoms. We need to pay more attention to the social communication deficits of TRTS.
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