Evidence map›Paper›PMID 36051592›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Peptide conformational imprints enhanced the catalytic activity of papain for esterification.

Kiran Reddy Kanubaddi, Ching-Lun Yang, Pei-Yu Huang, Chung-Yin Lin, Dar-Fu Tai, Chia-Hung Lee

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Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kiran Reddy KanubaddiDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.
Ching-Lun YangDepartment of Chemistry, National Dong Hwa University, Hualien, Taiwan.
Pei-Yu HuangDepartment of Chemistry, National Dong Hwa University, Hualien, Taiwan.
Chung-Yin LinMedical Imaging Research Center, Institute for Radiological Research, Chang Gung University, Taoyuan, Taiwan.
Dar-Fu TaiDepartment of Chemistry, National Dong Hwa University, Hualien, Taiwan.
Chia-Hung LeeDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptide conformational imprints (PCIs) offer a promising perspective to directly generate binding sites for preserving enzymes with high catalytic activity and stability. In this study, we synthesized a new chiral cross-linker cost-effectively for controlling the matrix morphology of PCIs on magnetic particles (PCIMPs) to stabilize their recognition capability. Meanwhile, based on the flank part of the sequences on papain (PAP), three epitope peptides were selected and synthesized. Molecularly imprinted polymers (MIPs) were then fabricated in the presence of the epitope peptide using our new cross-linker on magnetic particles (MPs) to generate PCIMPs. PCIMPs were formed with helical cavities that complement the PAP structure to adsorb specifically at the targeted position of PAP. PCIMPs

Indexed as

enzyme immobilizationesterificationmolecularly imprinted polymerspapainpeptide conformational imprints

Identifiers

PMID36051592
PMCPMC9424681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.