Evidence map›Paper›PMID 36051470›Full record

ArticleTherapeutic advances in medical oncology2022

Immunogenicity of SARS-CoV-2 vaccines in patients with breast cancer.

Elyssa Denault, Erika Nakajima, Vivek Naranbhai, Jennifer A Hutchinson, Lindsey Mortensen, Elizabeth Neihoff, Caroline Barabell, Amy Comander, Dejan Juric, Irene Kuter and 13 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in medical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 2 institutions in 1 country.

Elyssa DenaultMassachusetts General Hospital, Boston, MA, USA.
Erika NakajimaMassachusetts General Hospital, Boston, MA, USA.
Vivek NaranbhaiMassachusetts General Hospital, Boston, MA, USA.
Jennifer A HutchinsonMassachusetts General Hospital, Boston, MA, USA.
Lindsey MortensenMassachusetts General Hospital, Boston, MA, USA.
Elizabeth NeihoffMassachusetts General Hospital, Boston, MA, USA.
Caroline BarabellMassachusetts General Hospital, Boston, MA, USA.
Amy ComanderMassachusetts General Hospital, Boston, MA, USA.
Dejan JuricMassachusetts General Hospital, Boston, MA, USA.
Irene KuterMassachusetts General Hospital, Boston, MA, USA.
Theresa MulveyMassachusetts General Hospital, Boston, MA, USA.
Jeffrey PeppercornMassachusetts General Hospital, Boston, MA, USA.
Aron S RosenstockMassachusetts General Hospital, Boston, MA, USA.
Jennifer ShinMassachusetts General Hospital, Boston, MA, USA.
Neelima VidulaMassachusetts General Hospital, Boston, MA, USA.
Seth A WanderMassachusetts General Hospital, Boston, MA, USA.
Beverly MoyMassachusetts General Hospital, Boston, MA, USA.
Leif W EllisenMassachusetts General Hospital, Boston, MA, USA.
Steven J IsakoffMassachusetts General Hospital, Boston, MA, USA.
A John IafrateMassachusetts General Hospital, Boston, MA, USA.
Justin F GainorMassachusetts General Hospital, Boston, MA, USA.
Aditya BardiaMassachusetts General Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0003-4885-1157
Laura M SpringMassachusetts General Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0001-8904-3514
Harvard University · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To explore the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with breast cancer based on type of anticancer treatment. Methods: Patients with breast cancer had anti-spike antibody concentrations measured ⩾14 days after receiving a full SARS-CoV-2 vaccination series. The primary endpoint was IgA/G/M anti-spike antibody concentration. Multiple regression analysis was used to analyze log Results: Between 29 April and 20 July 2021, 233 patients with breast cancer were enrolled, of whom 212 were eligible for the current analysis. Patients who received mRNA-1273 (Moderna) had the highest antibody concentrations [geometric mean concentration (GMC) in log Conclusion: Most patients with breast cancer generate detectable anti-spike antibodies following SARS-CoV-2 vaccination, though systemic treatments and vaccine type impact level of response. Further studies are needed to better understand the clinical implications of different antibody levels, the effectiveness of additional SARS-CoV-2 vaccine doses, and the risk of breakthrough infections among patients with breast cancer.

Indexed as

breast cancerCDK4/6 inhibitorHER2+ breast cancerhormone receptor-positive breast cancertriple-negative breast cancer

Identifiers

PMID36051470
PMCPMC9425892
OpenAlexW4292827480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.