ArticleFrontiers in endocrinology2022
Increased risk of testosterone deficiency is associated with the systemic immune-inflammation index: a population-based cohort study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Association between a novel nutritional-inflammatory index and testosterone levels: a cross-sectional study.Sexual medicine · 2026Article
- The 24/7 lifestyle and male hormonal health: how sleep deprivation and ultra-processed foods impact testosterone and reproduction.Reviews in endocrine & metabolic disorders · 2026Review
- Prognostic Value of Albumin/Globulin Ratio for Mortality in Stage 2 Cardiovascular-Kidney-Metabolic Syndrome: A Nationwide Cohort Analysis (1999-2018).High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Comparative the predictive value of neutrophil-to-HDL ratio and monocyte-to-HDL ratio for early neurological deterioration in acute ischemic stroke patients following intravenous thrombolysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- System-level clustering of testosterone-related biomarkers identifies high-risk aging profiles linked to inflammation and renal function.Communications medicine · 2026Article
- Association between ethylene oxide exposure and serum sex hormone in adult males: the mediating role of serum albumin.Hormones (Athens, Greece) · 2026Article
- Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.International journal of molecular sciences · 2026Review
- Systemic immune-inflammation index as a novel biomarker for predicting surgical site infection in people living with HIV: a multicenter, retrospective cohort study.Frontiers in cellular and infection microbiology · 2026Observational
- Association between estimated glucose disposal rate and testosterone deficiency in male patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Association Between Dietary Intake of Omega-3 Fatty Acids and Serum Testosterone in Adult Males: Results From NHANES 2011-2016 and 2021-2023.Food science & nutrition · 2025Article
- Predictive role of the muscle quality index for testosterone deficiency in adult males based on interpretable machine learning methods.BMC public health · 2025Article
- Prognostic value of TIMI risk score combined with systemic immune-inflammation index and lipoprotein(a) in patients with ST-Segment elevation myocardial infarction after percutaneous coronary intervention.International journal of cardiology. Heart & vasculature · 2025Article
- Article
- Association between life's essential 8 and testosterone deficiency in men: NHANES 2011-2016.Frontiers in endocrinology · 2024Article
- Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population.Biomolecules · 2023Article
- Systematic analysis between inflammation-related index and sex hormones in American adults: cross-sectional research based NHANES 2013-2016.Frontiers in immunology · 2023Article
- The associations between dietary fibers intake and systemic immune and inflammatory biomarkers, a multi-cycle study of NHANES 2015-2020.Frontiers in nutrition · 2023Article
- Increased Systemic Immune-Inflammation Index Was Associated with Type 2 Diabetic Peripheral Neuropathy: A Cross-Sectional Study in the Chinese Population.Journal of inflammation research · 2023Article
- Association between the prevalence rates of circadian syndrome and testosterone deficiency in US males: data from NHANES (2011-2016).Frontiers in nutrition · 2023Article
- Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018.Frontiers in endocrinology · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to explore the relationship between serum testosterone levels and systemic immune-inflammation index (SII). Methods: Complete SII and serum testosterone data of men over 20 years of age were retrieved from the 2011-2016 National Health and Nutrition Examination Survey to conduct a prevalence survey. To calculate SII, the platelet count was multiplied by the neutrophil-to-lymphocyte count ratio. Isotope dilution liquid chromatography and tandem mass spectrometry were employed to measure serum testosterone concentration. Testosterone deficiency (TD) was defined as a serum testosterone level ≤ 300ng/dl. Weighted proportions and multivariable regression analyses were used to analyze the association between SII and TD. Results: Overall, the data of 7389 participants were analyzed, The SII ranged from 1.53 - 6297.60. Of the participants, 28.42% had a low serum testosterone level (≤ 300 ng/dl). In the fully adjusted multivariable logistic model, the second quartile (OR: 1.27, p = 0.0737), the third quartile (OR: 1.43, p = 0.0090), and the fourth quartile (OR:1.48, p = 0.0042) of SII significantly increased the TD incidence rate, with the lowest quartile of the SII as a reference. For subgroup analysis, statistically significant associations were observed in participants aged 20-40, obese, non-hypertensive, and non-diabetic. The interaction test revealed no significant effect on this connection. Conclusions: There was a positive relationship between a high SII and an increased prevalence of TD in a nationwide sample of adult men in the United States. Further prospective studies on a larger scale are warranted to confirm the causality between SII and TD.
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