Evidence map›Paper›PMID 36051263›Full record

ArticleHeliyon2022

Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction.

Kenichi Watanabe, Masao Hirayama, Somasundaram Arumugam, Masayoshi Sugawara, Hisanori Kato, Sumiko Nakamura, Ken'ichi Ohtsubo, Hitoshi Matsumoto, Yuri Nomi, Noriyuki Homma and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Kenichi WatanabeDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Masao HirayamaNiigata Bio-Research Park Co., Ltd., Japan.
Somasundaram ArumugamDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Masayoshi SugawaraDepartment of Materials Engineering, National Institute of Technology, Nagaoka College, Japan.
Hisanori KatoGraduate School of Agriculture and Life Sciences, The University of Tokyo, Japan.
Sumiko NakamuraFaculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.
Ken'ichi OhtsuboFaculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.
Hitoshi MatsumotoFaculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.
Yuri NomiFaculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.
Noriyuki HommaCereal Food Section, Niigata Agricultural Research Institute Food Research Center, Japan.
Yoshifumi FujiiNiigata-Seifun Co., Ltd., Japan.
Naoto MurohashiBourbon Institutes of Health, Bourbon Corporation, Japan.
Rajarajan A ThandavarayanDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Hiroshi SuzukiDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Kazuya FujiharaDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Satoru KodamaDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Hirohito SoneDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Niigata University · JPNiigata University of Pharmacy and Medical and Life Sciences · JPNiigata Agricultural Research Institute · JPHouston Methodist · USNagaoka National College of Technology · JPNational Institute of Pharmaceutical Education and Research · INNisshin Seifun Group (Japan) · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endothelial dysfunction is an early pathophysiological feature and independent predictor of a poor prognosis in most forms of cardiovascular disease. We evaluated the effect of brown rice crackers (BR-C) on endothelial function. Methods: Effect of heat-moisture treated (HMT) -BR-C on postprandial flow-mediated dilation (FMD) in adults with mild endothelial dysfunction was compared with that of BR-C and white rice crackers (WR-C) in 12 adults with mild endothelial dysfunction (less than 7.0% of FMD) by a randomized, single-blind, three-treatment three-period crossover trial (UMIN 000034898). Since we considered that the FMD increase was associated with the treatment of HMT-BR-C, we examined the effect of three possible factors: postprandial glucose levels, polyphenol content, and polyphenol release from the food matrix. Results: Mean pre-intake baseline FMD values of HMT-BR-C, BR-C, and WR-C were 4.9%, 5.1%, and 4.9%, respectively, and those values 1 h post-intake were 6.3%, 5.1%, and 4.8%, respectively. There was no difference in intergroup comparisons of FMD using Dunnett's multiple comparison test. There was a significant increase in FMD only in HMT-BR-C in intragroup comparisons ( Conclusion: HMT-BR-C intake increased the postprandial FMD response.

Indexed as

Blood glucoseCrossover trialFlow-mediated dilation (FMD)Heat-moisture treated (HMT) brown rice crackerPolyphenols

Identifiers

PMID36051263
PMCPMC9424955
OpenAlexW4292478802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.