Evidence map›Paper›PMID 36051162›Full record

ArticleEuropean journal of case reports in internal medicine2022

Restless Chest Syndrome: A Rare Variant of Restless Legs Syndrome.

Kosuke Ishizuka, Yoshiyuki Ohira

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in European journal of case reports in internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07453862 (Observation of Efficacy and Safety of Novel Calcium Channel Modulators in the Treatment of Restless Legs Syndrome and Its Variant Subtypes), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07453862 phase1recruitingnot on this mapstarted 2026, after this paper: background citation

Observation of Efficacy and Safety of Novel Calcium Channel Modulators in the Treatment of Restless Legs Syndrome and Its Variant Subtypes

TypeinterventionalSponsorBeijing Friendship HospitalRan2026 to 2027Enrolled20ConditionsRestless Leg Syndrome (RLS), Variant Restless Legs SyndromeArmsCrisugabalin
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kosuke IshizukaDivision of General Internal Medicine, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki-city, Japan.
Yoshiyuki OhiraDivision of General Internal Medicine, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki-city, Japan.
St. Marianna University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 23-year-old Japanese woman presented with a 1-month history of dyspnoea and chest discomfort. Since the symptoms improved with dynamic and sensory stimulation and also caused insomnia, we considered a variant of restless legs syndrome (RLS) called 'restless chest syndrome', although there were no symptoms in the extremities. We initiated oral administration of pramipexole 0.25 mg daily, and her symptoms, including dyspnoea, chest discomfort and insomnia, improved within 1 week. RLS should be considered in the differential diagnosis in patients who present with abnormal sensations that worsen at night, with insomnia, regardless of the site of the symptoms. LEARNING POINTS: In restless legs syndrome, rare localised sensations in the chest, back, abdomen, face, arm and perineum rather than the lower extremities, have been reported.Dynamic stimuli, intellectual activity and sensory stimuli have been reported to temporarily ease restless legs syndrome symptoms.Restless legs syndrome should be considered in patients who present with abnormal sensations that worsen at night, with insomnia, regardless of the site of the symptoms.

Indexed as

Restless chest syndromerestless legs syndrome

Identifiers

PMID36051162
PMCPMC9426964
OpenAlexW4283834805

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.