Evidence map›Paper›PMID 36051066›Full record

ArticleEJHaem2022

Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells.

May Eriksen-Gjerstad, Ida Tveit Karlsen, Zinayida Fandalyuk, Susanne Benjaminsen, Fanny Baran-Marszak, Bela Papp, Frederick Locke, Marcus Ladds, Andrés Pastor-Fernández, Pascal Gelebart and 1 more

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

May Eriksen-GjerstadDepartment of Clinical Science University of Bergen Bergen Norway.
Ida Tveit KarlsenDepartment of Clinical Science University of Bergen Bergen Norway.
Zinayida FandalyukDepartment of Clinical Science University of Bergen Bergen Norway.
Susanne BenjaminsenDepartment of Clinical Science University of Bergen Bergen Norway.
Fanny Baran-MarszakInserm U978 Université Paris-13 Bobigny France.
Bela PappInstitut National de la Santé et de la Recherche Médicale UMR U976 Institut de Recherche Saint-Louis Hôpital Saint-Louis, Université de Paris; CEA DRF-Institut Francois Jacob Department of Hemato-Immunology Research Hôpital Saint-Louis Paris France.
Frederick LockeDepartment of Blood and Marrow Transplant and Cellular Therapy Moffit Cancer Centre Tampa USA.
Marcus LaddsDepartment of Microbiology Tumor and Cell Biology (MTC) Karolinska Institutet Stockholm Sweden.
Andrés Pastor-FernándezDepartment of Microbiology Tumor and Cell Biology (MTC) Karolinska Institutet Stockholm Sweden.
Pascal GelebartDepartment of Clinical Science University of Bergen Bergen Norway.ORCID https://orcid.org/0000-0003-2434-8987
Emmet Mc CormackDepartment of Clinical Science University of Bergen Bergen Norway.
University of Bergen · NOScience for Life Laboratory · SECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInserm · FRMoffitt Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma that remains incurable with the treatment options available today. In the present study, we have identified the dihydroorotate dehydrogenase (DHODH), an essential enzyme for the

Indexed as

apoptosisDHODHmantle cell lymphomatargeted therapy

Identifiers

PMID36051066
PMCPMC9422018
OpenAlexW4280639530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.