Evidence map›Paper›PMID 36051063›Full record

ArticleEJHaem2022

Lower access to risk stratification tests and drugs, and worse survival of chronic lymphocytic leukaemia patients treated in public as compared to private hospitals in Brazil: A retrospective analysis of the Brazilian registry of chronic lymphocytic leukaemia.

Verena Pfister, Fernanda de Morais Marques, Flavia Parra, Mihoko Yamamoto, Matheus Vescovi Gonçalves, Leila Perobelli, Valeria Buccheri, Raphael Bandeira, Sergio Fortier, Alita Azevedo and 10 more

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 12 institutions in 1 country.

Verena PfisterEscola Paulista de Medicina /Universidade Federal de São Paulo, UNIFESP São Paulo Brazil.ORCID https://orcid.org/0000-0002-2061-1277
Fernanda de Morais MarquesEscola Paulista de Medicina /Universidade Federal de São Paulo, UNIFESP São Paulo Brazil.
Flavia ParraBrazilian Registry of CLL - Associação Brasileira de Hematologia e Hemoterapia Hemoterapia Brazil.
Mihoko YamamotoEscola Paulista de Medicina /Universidade Federal de São Paulo, UNIFESP São Paulo Brazil.
Matheus Vescovi GonçalvesEscola Paulista de Medicina /Universidade Federal de São Paulo, UNIFESP São Paulo Brazil.
Leila PerobelliHospital Brigadeiro São Paulo Brazil.
Valeria BuccheriICESP Faculdade de Medicina da USP São Paulo Brazil.ORCID https://orcid.org/0000-0002-6999-4109
Raphael BandeiraICESP Faculdade de Medicina da USP São Paulo Brazil.
Sergio FortierSanta Casa de São Paulo São Paulo Brazil.
Alita AzevedoHEMOPE Recife Brazil.
Rodrigo SantucciHemomed São Paulo Brazil.
Marcelo BellessoHemomed São Paulo Brazil.
Laura FogliattoHospital das Clínicas de Porto Alegre Porto Alegre Brazil.
Glaciano RibeiroUniversidade Federal de Minas Gerais Belo Horizonte Brazil.
Germison Silva LopesUniversidade Federal do Ceará Fortaleza Brazil.
Maura IkomaHospital Amaral Carvalho Jaú Brazil.
Vera P FigueiredoHospital do Servidor Público Estadual São Paulo Brazil.
Irene Gyongyver H Lorand MetzeUniversidade Estadual de Campinas, UNICAMP Campinas Brazil.ORCID https://orcid.org/0000-0002-6516-1265
Carlos Sérgio ChiattoneSanta Casa de São Paulo São Paulo Brazil.
Celso Arrais-RodriguesEscola Paulista de Medicina /Universidade Federal de São Paulo, UNIFESP São Paulo Brazil.
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas · BRDr. Euryclides Hospital de Jesus Zerbini · BRInstituto do Câncer do Estado de São Paulo · BRUniversidade Federal de São Paulo · BRFundação Hemopa · BRHospital Amaral Carvalho · BRHospital de Clínicas de Porto Alegre · BRHospital do Servidor Público Estadual · BRHospital Samaritano de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic lymphocytic leukaemia (CLL) has a highly variable clinical course. In addition to biological factors, socioeconomic factors and health system characteristics may influence CLL outcome. Data from the Brazilian Registry of CLL were analyzed to compare clinical and treatment-related characteristics in patients with CLL, from public or private institutions. A total of 3326 patients from 43 centres met the eligibility criteria, of whom 81% were followed up at public hospitals and 19% at private hospitals. The majority were male (57%), with a median age of 65 years. Comparing public and private hospitals, patients in public hospitals were older, had more advanced disease at diagnosis, and more frequently had elevated creatinine levels. All investigated prognostic markers were evaluated more often in private hospitals. First-line treatment was predominantly based on chlorambucil in 41% of the cases and fludarabine in 38%. Anti-CD20 monoclonal antibody was used in only 36% of cases. In public hospitals, significantly fewer patients received fludarabine-based regimens and anti-CD20 monoclonal antibodies. Patients from public hospitals had significantly worse overall survival (71% vs. 90% for private hospitals,

Indexed as

CLLpublic health systemrisk stratification

Identifiers

PMID36051063
PMCPMC9422035
OpenAlexW4229022175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.