Evidence map›Paper›PMID 36051042›Full record

ArticleEJHaem2022

Acute lymphoblastic leukemia with clonal evolution due to delay in chemotherapy: A report of a case.

Ahmed Maseh Haidary, Ramin Saadaat, Jamshid Abdul-Ghafar, Soma Rahmani, Sarah Noor, Sahar Noor, Najla Nasir, Maryam Ahmad, Ahmad Shekib Zahier, Rohullah Zahier and 7 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Ahmed Maseh HaidaryDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.ORCID https://orcid.org/0000-0002-4554-8024
Ramin SaadaatDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Jamshid Abdul-GhafarDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Soma RahmaniDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Sarah NoorDepartment of Haemato-Oncology Ali Abad Hospital Kabul Afghanistan.
Sahar NoorDepartment of Paediatric Medicine French Medical Institute for Mothers and Children Kabul Afghanistan.
Najla NasirDepartment of Internal Medicine Rabia Balkhi Hospital Kabul Afghanistan.
Maryam AhmadDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Ahmad Shekib ZahierDepartment of Haemato-Oncology Amiri Medical Complex Kabul Afghanistan.
Rohullah ZahierDepartment of Internal Medicine Istiqlal Hospital Kabul Afghanistan.
Haider Ali MalakzaiDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Abdul Sami IbrahimkhilDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Samuel SharifDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Tawab BaryaliDepartment of Quality Assurance French Medical Institute for Mothers and Children Kabul Afghanistan.
Inamullah MohibDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Abdul Hadi SaqibDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children Kabul Afghanistan.
Raja Zahratul AzmaFaculty of Medicine Department of Pathology Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia.
Kabul Medical University · AFKabul University · AFBalkh University · AFNational University of Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clonal evolution in acute leukemias is one of the most important factors that leads to therapeutic failure and disease relapse. Delay in therapeutic intervention is one of the reasons that leads toward clonal evolution. In this report, we present a case of acute lymphoblastic leukemia in which therapeutic delay resulted in clonal evolution that was detected by conventional karyotyping and was responsible for non-responsiveness of the disease to conventional chemotherapy. A 17-year-old boy presented with generalized body aches, rapidly progressive pallor and lethargy. Bone marrow analysis was consistent with the diagnosis of B-cell ALL. Karyotypic analysis revealed 46, XY male karyotype. The patient left the hospital due to financial reasons and after 40 days came back to the hospital. Repeated bone marrow analysis including cytogenetic studies revealed presence of three different clones of blast cells: one clone showed 46, XY with del(9p) and t (11;14), second clone showed 46, XY with del(7q) and del(9p), and the third clone showed 46, XY normal karyotype. The patient did not respond to chemotherapy and died within 1 week of induction chemotherapy (HyperCVAD-A). Timely diagnosis and institution of chemotherapy in acute leukemias patients is the key to prevent clonal evolution and thus resistance of the disease to therapeutic interventions.

Indexed as

ALLclonal evolutiondelayed chemotherapy

Identifiers

PMID36051042
PMCPMC9421991
OpenAlexW4281950750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.