Evidence map›Paper›PMID 36051013›Full record

ArticleEJHaem2022

Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT.

Niels Jacobsen, Tina Frisch, Niels Keiding, Carsten Heilmann, Henrik Sengeløv, Hans O Madsen, Ebbe Dickmeiss, Lars P Ryder

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Niels JacobsenDepartment of Hematology Rigshospitalet University Hospital Copenhagen Denmark.ORCID https://orcid.org/0000-0002-7645-9593
Tina FrischDepartment of Clinical Immunology Tissue Typing Laboratory Rigshospitalet University Hospital Copenhagen Denmark.
Niels KeidingDepartment of Biostatistics Faculty of Health Sciences Copenhagen University Copenhagen Denmark.
Carsten HeilmannPaediatric and Adolescence Medicine Rigshospitalet University Hospital Copenhagen Denmark.
Henrik SengeløvDepartment of Hematology Rigshospitalet University Hospital Copenhagen Denmark.
Hans O MadsenDepartment of Clinical Immunology Tissue Typing Laboratory Rigshospitalet University Hospital Copenhagen Denmark.
Ebbe DickmeissDepartment of Clinical Immunology Tissue Typing Laboratory Rigshospitalet University Hospital Copenhagen Denmark.
Lars P RyderDepartment of Clinical Immunology Tissue Typing Laboratory Rigshospitalet University Hospital Copenhagen Denmark.
Rigshospitalet · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of higher FOXP3 mRNA expression by recipient pre-transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (

Indexed as

acute leukaemiaFOXP3haematopoietic stem cell transplantationHSCTTreg cells

Identifiers

PMID36051013
PMCPMC9421961
OpenAlexW4225164771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.