Evidence map›Paper›PMID 36051011›Full record

ArticleEJHaem2022

Aiding early clinical drug development by elucidation of the relationship between tumor growth inhibition and survival in relapsed/refractory multiple myeloma patients.

Yiming Cheng, Kevin Hong, Nianhang Chen, Xin Yu, Teresa Peluso, Simon Zhou, Yan Li

Abstract read
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiming ChengClinical Pharmacology & Pharmacometrics Bristol Myers Squibb New Jersey USA.ORCID https://orcid.org/0000-0001-5428-9418
Kevin HongGlobal Drug Development Bristol Myers Squibb New Jersey USA.
Nianhang ChenClinical Pharmacology & Pharmacometrics Bristol Myers Squibb New Jersey USA.
Xin YuGlobal Biometric Sciences Bristol Myers Squibb New Jersey USA.
Teresa PelusoGlobal Drug Development Bristol Myers Squibb Boudry Switzerland.
Simon ZhouClinical Pharmacology & Pharmacometrics Bristol Myers Squibb New Jersey USA.
Yan LiClinical Pharmacology & Pharmacometrics Bristol Myers Squibb New Jersey USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early prognosis of clinical efficacy is an urgent need for oncology drug development. Herein, we systemically examined the quantitative approach of tumor growth inhibition (TGI) and survival modeling in the space of relapsed and refractory multiple myeloma (MM), aiming to provide insights into clinical drug development. Longitudinal serum M-protein and progression-free survival (PFS) data from three phase III studies (

Indexed as

M‐proteinmultiple myelomaprogression‐free survival (PFS)tumor growth inhibition (TGI)

Identifiers

PMID36051011
PMCPMC9422038

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.