Evidence map›Paper›PMID 36050866›Full record

ArticleJournal of cellular and molecular medicine2022

Synthesis and evaluation of a novel analgesic conotoxin Lt7b that inhibits calcium currents and increases sodium currents.

Yun Wu, Manyi Yang, Yubin Li, Wei Zhang, Maojun Zhou

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Yun WuGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.
Manyi YangDepartment of Hepatobiliary and Pancreatic Surgery, NHC Key Laboratory of Nanobiological Technology, Xiangya Hospital, Central South University, Changsha, China.
Yubin LiDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital, Central South University, Changsha, China.
Wei ZhangInstitute of High Energy Physics, Chinese Academy of Sciences, Shijingshan District, China.
Maojun ZhouDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-0603-5223
Central South University · CNChinese Academy of Sciences · CNGuangdong Medical College · CN

Funding

Foundation for Distinguished Young Talents in Higher Education of Guangdong 2018KQNCX089Guangdong Basic and Applied Basic Research Foundation 2020A1515111040National Natural Science Foundation of China 81703412Natural Science Foundation of Hunan Province 2021JJ30914Natural Science Foundation of Hunan Province 2022JJ30974the Medical Scientific Research Foundation of Guangdong Province B2021197
6 · The paper itself

Abstract

Conotoxins are promising neuropharmacological tools and drug candidates due to their high efficiency and specificity in targeting ion channels or neurotransmitter receptors. In this study, a novel O

Indexed as

AnalgesicsConotoxinsAmino AcidsAnimalsCalciumDisulfidesMicePotassiumRatsReceptors, NeurotransmitterRNASodiumAmino AcidsAnalgesicsCalciumConotoxinsDisulfidesPotassiumReceptors, NeurotransmitterRNASodiumcalcium channel blockersconopeptideconotoxinconus literatusLt7bpainsodium currents

Identifiers

PMID36050866
PMCPMC9575111
OpenAlexW4294176810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.