Evidence map›Paper›PMID 36050826›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2023

Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care.

Rachael Jacob, David S Prince, Joseph L Pipicella, Angela Nguyen, Melissa Bagatella, Frank Alvaro, Michael Maley, Hong Foo, Paul Middleton, Tahrima Kayes and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care.Liver international : official journal of the International Association for the Study of the Liver · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Rachael JacobDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.ORCID 0000-0002-7195-3154
David S PrinceDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.ORCID 0000-0001-8087-0548
Joseph L PipicellaDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.ORCID 0000-0002-1796-918X
Angela NguyenDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.
Melissa BagatellaDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.
Frank AlvaroDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.
Michael MaleyDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.
Hong FooDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.
Paul MiddletonDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.
Tahrima KayesDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.ORCID 0000-0001-8927-3635
Julia DiGirolamoDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.
Scott A DavisonDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.
Miriam T LevyDepartment of Gastroenterology and Liver, Liverpool Hospital, Sydney, New South Wales, Australia.ORCID 0000-0001-9329-8018
Liverpool Hospital · AUNew South Wales Department of Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSignificant barriers exist with hepatitis B (HBV) case detection and effective linkage to care (LTC). The emergency department (ED) is a unique healthcare interaction where hepatitis screening and LTC could be achieved. We examined the efficacy and utility of automated ED HBV screening for Overseas Born (OB) patients.

methodsA novel-automated hepatitis screening service "SEARCH" (Screening Emergency Admissions at Risk of Chronic Hepatitis) was piloted at a metropolitan hospital. A retrospective and comparative analysis of hepatitis testing during the SEARCH pilot compared to a period of routine testing was conducted.

resultsDuring the SEARCH pilot, 4778 OB patients were tested for HBV (86% of eligible patient presentations), compared with 1.9% of eligible patients during a control period of clinician-initiated testing. SEARCH detected 108 (2.3%) hepatitis B surface antigen positive patients including 20 (19%) in whom the diagnosis was new. Among 88 patients with known HBV, 57% were receiving medical care, 33% had become lost to follow-up and 10% had never received HBV care. Overall, 30/88 (34%) patients with known HBV were receiving complete guideline-based care prior to re-engagement via SEARCH. Following SEARCH, LTC was successful achieved in 48/58 (83%) unlinked patients and 19 patients were commenced on anti-viral therapy. New diagnoses of cirrhosis and hepatocellular carcinoma were made in five and one patient(s) respectively.

conclusionsAutomated ED screening of OB patients is effective in HBV diagnosis, re-diagnosis and LTC. Prior to SEARCH, the majority of patients were not receiving guideline-based care.

Indexed as

Hepatitis BHepatitis B, ChronicLiver NeoplasmsHepatitis B Surface AntigensHepatitis B virusHepatitis, ChronicHumansMass ScreeningRetrospective StudiesHepatitis B Surface Antigenshepatitis Blinkage to careuniversal screening

Identifiers

PMID36050826
PMCPMC10087472
OpenAlexW4294148133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.