ArticleJournal of animal science and biotechnology2022
Phytogenic feed additives alleviate pathogenic Escherichia coli-induced intestinal damage through improving barrier integrity and inhibiting inflammation in weaned pigs.
Article in Journal of animal science and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Phloretin as a functional feed bioactive in livestock: Biological role, biosynthesis, and practical applications.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Thymol modulates rumen barrier function and inflammation in feed-restricted lambs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effects of a multi-nutrient feed additive on the growth performance, gut health, and antioxidant status of weaned piglets.Tropical animal health and production · 2026Article
- Identifying the optimal ratios for replacing spray-dried plasma protein with hydrolyzed porcine intestinal protein in weaning pig.Journal of animal science and technology · 2026Article
- Dietary supplementation with sodium isobutyrate enhances growth performance and colonic barrier function in weaned piglets via microbiota-metabolite-host interactions.Journal of animal science and biotechnology · 2025Article
- Probiotics, Prebiotics, and Synbiotics in Pigs and Poultry: A Review of Gut Health, Performance, and Environmental Outcomes.Veterinary sciences · 2025Review
- From Bench to Piglet: A Comparison of In Vivo and In Vitro Effects of Phytogenics on Post-Weaning Diarrhea, Growth Performance, and Bacterial Behavior.Animals : an open access journal from MDPI · 2025Article
- The impact of combined thymol and rosmarinic acid on the intestinal microbiota and barrier function of the piglets challenged byAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Investigation of the nutritional and functional roles of a microencapsulated blend of botanicals on intestinal health and growth of nursery pigs challenged with F18+Escherichia coli.Journal of animal science · 2025Article
- Effects of probiotics on growth performance, intestinal morphology, intestinal microbiota weaning pig challenged withJournal of animal science and technology · 2025Article
- Alternatives to antibiotics for sustainable livestock production in the context of the One Health approach: tackling a common foe.Frontiers in veterinary science · 2025Review
- Effects of β-Mannanase Alone or Combined with Multi-Carbohydrase Complex in Corn-Soybean Meal Diets on Nutrient Metabolism and Gut Health of Growing Pigs.Animals : an open access journal from MDPI · 2024Article
- The Effects of Octapeptin Supplementation on Growth Performance, Serum Biochemistry, Serum Immunity, and Gut Microbiota in Weaned Piglets.Animals : an open access journal from MDPI · 2024Article
- Effects of dietary supplementation with a carvacrol-cinnamaldehyde-thymol blend on growth performance and intestinal health of nursery pigs.Porcine health management · 2023Article
- Effects of different stocking density and various phytogenic feed additives dosage levels on growing-finishing pigs.Journal of animal science and technology · 2023Article
- Beneficial Effects of Phytogenic Feed Additives on Epithelial Barrier Integrity in an In Vitro Co-Culture Model of the Piglet Gut.Molecules (Basel, Switzerland) · 2023Article
- Summary of methodology used in enterotoxigenicTranslational animal science · 2023Review
- Effects of stimbiotic supplementation on gut health, immune response, and intestinal microbiota in weaned piglets challenged withFrontiers in veterinary science · 2023Article
- Cutting-edge knowledge on the roles of phytobiotics and their proposed modes of action in swine.Frontiers in veterinary science · 2023Review
- Swine enteric colibacillosis: Current treatment avenues and future directions.Frontiers in veterinary science · 2022Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThis study was conducted to investigate the effects of each phytogenic feed additive (PFA; PFA1, bitter citrus extract; PFA2, a microencapsulated blend of thymol and carvacrol; PFA3, a mixture of bitter citrus extract, thymol, and carvacrol; PFA4, a premixture of grape seed, grape marc extract, green tea, and hops; PFA5, fenugreek seed powder) on the growth performance, nutrient digestibility, intestinal morphology, and immune response in weaned pigs infected with Escherichia coli (E. coli).
resultsA total of 63 4-week-old weaned pigs were placed in individual metabolic cages and assigned to seven treatment groups. The seven treatments were as follows: 1) NC; basal diet without E. coli challenge, 2) PC; basal diet with E. coli challenge, 3) T1; PC + 0.04% PFA1, 4) T2; PC + 0.01% PFA2, 5) T3; PC + 0.10% PFA3, 6) T4; PC + 0.04% PFA4, 7) T5; PC + 0.10% PFA5. The experiments lasted in 21 d, including 7 d before and 14 d after the first E. coli challenge. In the E. coli challenge treatments, all pigs were orally inoculated by dividing a total of 10 mL of E. coli F18 for 3 consecutive days. The PFA-added groups significantly increased (P < 0.05) average daily gain and feed efficiency and decreased (P < 0.05) the fecal score at d 0 to 14 post-inoculation (PI). Tumor necrosis factor α was significantly lower (P < 0.05) in the PFA-added groups except for T1 in d 14 PI compared to the PC treatment. The T3 had a higher (P < 0.05) immunoglobulin G and immunoglobulin A concentration compared to the PC treatment at d 7 PI. Also, T3 showed significantly higher (P < 0.05) villus height:crypt depth and claudin 1 expression in ileal mucosa, and significantly down-regulated (P < 0.05) the expression of calprotectin compared to the PC treatment.
conclusionsSupplementation of PFA in weaned pigs challenged with E. coli alleviated the negative effects of E. coli and improved growth performance. Among them, the mixed additive of bitter citrus extract, thymol, and carvacrol showed the most effective results, improving immune response, intestinal morphology, and expression of tight junctions.
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