Evidence map›Paper›PMID 36050693›Full record

ArticleWorld journal of surgical oncology2022

Assessment of galectins -1, -3, -4, -8, and -9 expression in ovarian carcinoma patients with clinical implications.

Radwa Mansour Mohamed, Athar Emam, Mahmoud M Abdelfattah, Abdel-Mageed Ismail Abdel-Mageed, Mohamed A Abdelhafeez, Reham Helwa

Open access · goldAbstract read
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Article in World journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Radwa Mansour MohamedDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Athar EmamDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mahmoud M AbdelfattahMolecular Cancer Biology group, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Abdel-Mageed Ismail Abdel-MageedDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed A AbdelhafeezDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Reham HelwaMolecular Cancer Biology group, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt. Reham.helwa@sci.asu.edu.eg.
Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimGalectins have been recently tackled by many researchers in the field of cancer due to their role in tumorigenesis, disease progression, and metastasis. Thus, they are currently involved in biomarkers research on several types of cancer. In ovarian cancers, few studies were carried out to evaluate galectins expression profiling. Hence, our present study was executed to evaluate the mRNA expression of galectins -1, -3, -4, -8, and -9 in epithelial ovarian cancers.

methodsFifty-six tumor samples of ovarian carcinomas were analyzed for mRNA expression using qRT-PCR, and fold-changes were calculated in comparison to tissue samples of 26 women with normal ovaries.

resultsThe results of the present paper emphasize the importance of galectins as predictors for targeted therapy. LGALS1, LGALS3, LGALS4, LGALS8, and LGALS9 were found to be mostly overexpressed in ovarian carcinoma patients with the following percentage: 78.6%, 92.9%, 66.1%, 87.5%, and 85.7% respectively. Moreover, galectins -3 and -9 were found to be significantly elevated with lymph node metastasis (p = 0.044 and p = 0.011). Also, upregulation of galectin-1 and -9 were statistically significant in stages IIB, IIC, and IIIB (p = 0.002) in FIGO staging. CA19.9 is positively correlated to galectin-4 expression (p = 0.039).

conclusionOur findings strengthen the role of galectins in carcinogenesis, disease progression, and lymphnode metastasis in ovarian carcinomas. And since these galectins are mostly overexpressed, they could be promising markers for targeted therapy to reduce disease progression and metastasis process.

Indexed as

CarcinomaGalectinsOvarian NeoplasmsCarcinoma, Ovarian EpithelialDisease ProgressionFemaleGalectin 1Galectin 3HumansLymphatic MetastasisRNA, MessengerGalectin 1Galectin 3GalectinsLGALS8 protein, humanRNA, MessengerBiomarkersGalectinsLymph node metastasismRNAOvarian carcinomaqRT-PCR

Identifiers

PMID36050693
PMCPMC9434928
OpenAlexW4294307532

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.