Evidence map›Paper›PMID 36050690›Full record

ArticlePediatric rheumatology online journal2022

Multisystem inflammatory syndrome in a fully vaccinated 18-year-old without known SARS-CoV-2 infection.

Andy Liu, Alexa Love, Sophie Katz, Anna Patrick, David Parra, Natasha Halasa, Michael R Miller

Open access · goldAbstract readCase Reports
In one paragraph

Article in Pediatric rheumatology online journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andy LiuDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. chi.an.liu@vumc.org.ORCID http://orcid.org/0000-0003-3256-0697
Alexa LoveDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Sophie KatzDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
Anna PatrickDivision of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA.
David ParraDivision of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Natasha HalasaDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael R MillerDivision of Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · USMonroe Carell Jr. Children's Hospital · US

Funding

Pathogenesis, Targeted Therapeutics, and New Vaccines for Childhood DiseaseK12HD087023 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Michael R. DeBaun, Juan C Salazar · 2016 to 2026
$4.1M
NICHD NIH HHS K12 HD087023
6 · The paper itself

Abstract

backgroundMultisystem inflammatory syndrome in children (MIS-C) is a febrile syndrome that is observed in the pediatric population following severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Vaccines have prevented or lessened the severity of the initial acute respiratory infection, while their effectiveness against severe MIS-C is just beginning to be reported. CASE PRESENTATION: Here we report a fully vaccinated teenage female with no known history of SARS-CoV-2 infection who presented with shock and heart failure. Her presentation was initially thought secondary to a retropharyngeal abscess but was later identified as MIS-C after confirmed nucleocapsid antibody.

conclusionsGiven the recent Omicron waves, the ongoing international outbreaks with evolving variants and the continued evolution of the COVID-19 pandemic, this case emphasizes the need to include MIS-C in the differential diagnosis, even in a fully vaccinated, previously healthy child.

Indexed as

COVID-19COVID-19 VaccinesSystemic Inflammatory Response SyndromeAdolescentFemaleHumansPandemicsCOVID-19 VaccinesCOVID-19MIS-CSARS-CoV-2Vaccination

Identifiers

PMID36050690
PMCPMC9434514
OpenAlexW4294024832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.