Evidence map›Paper›PMID 36050617›Full record

Trial reportObesity surgery2022

Paragastric Autonomic Neural Blockade to Prevent Early Visceral Pain and Associated Symptoms After Laparoscopic Sleeve Gastrectomy: a Randomized Clinical Trial.

Jorge Daes, David J Morrell, Andrés Hanssen, Melissa Caballero, Elika Luque, Rafael Pantoja, Jorge Luquetta, Eric M Pauli

9 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05668845 nacompletednot on this mapstarted 2023, after this paper: background citation

Paragastric Autonomic Neural Blockade as Part of Combined Anesthesia. Impact on Anesthetic Agents Consumption: A Randomized Clinical Trial Protocol

TypeinterventionalSponsorUniversidad Simón BolívarRan2023 to 2023Enrolled79ConditionsOpioid Use, Anesthesia MorbidityArmsPG-ANB performed at the outset of LSG, PG-ANB performed at the end of the LSG
NCT05984160 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Efficacy and Safety of Paragastric Neural Block in Controlling Pain, Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy; Prospective Randomized Controlled Double-blind Study

TypeinterventionalSponsorAtlas UniversityRan2023 to 2023Enrolled90ConditionsObesity, Post Operative PainArmsParagastric neural block
NCT06137924 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

Intraoperative Autonomic Neural Blockade (ANB) Comparison Between Different Local Anesthetic Combinations. A Randomized Clinical Trial Protocol

TypeinterventionalSponsorUniversidad Simón BolívarRan2023 to 2024Enrolled150ConditionsPain, Postoperative, Nausea, Postoperative, Vomiting, Postoperative, AnalgesiaArmsLocal anesthetic injection Bupivacaine plus dexamethasone, Local anesthetic injection bupivacainde plus dexamethasone plus a colloid, Local anesthetic injection bupivacaine plus clonidine
NCT06753500 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Intraoperative Autonomic Blockade to Prevent Early Postoperative Pain After Laparoscopic Cholecystectomy: A Double-Blind, Randomized Controlled Trial

TypeinterventionalSponsorUniversidad Simón BolívarRan2025 to 2025Enrolled60ConditionsVisceral Pain, Analgesia, Opioid Use, Postoperative NauseaArmsAutonomic neural blockade
NCT06973122 nacompletednot on this mapstarted 2025, after this paper: background citation

Effect of Combined Paragastric Autonomic Neural Blockade and Laparoscopic Assisted Transversus Abdominis Plane Block on Visceral Pain After Bariatric Surgery

TypeinterventionalSponsorAlexandria UniversityRan2025 to 2025Enrolled127ConditionsVisceral PainArmscombined paragastric autonomic neural blockade and laparoscopic assisted transversus abdominis plane block, laparoscopic assisted transversus abdominis plane block
NCT07104825 narecruitingnot on this mapstarted 2026, after this paper: background citation

Autonomic Neural Blockade During Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial Evaluating Pain and Nausea After Bariatric Surgery

TypeinterventionalSponsorEndeavor HealthRan2026 to 2027Enrolled200ConditionsBariatric Surgery Candidate, Pain, Postoperative, Nausea and Vomiting, Postoperative, Opioid UseArmsIntraoperative autonomic neural blockade (ANB), Laparoscopic Standard of Care Abdominal Wall Block
NCT07351994 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Autonomic Neural Field Block for Visceral Pain Control in Minimally Invasive Left-Sided Colorectal Resections

Typeobservational_patient_registrySponsorAntonio Caycedo, MDRan2026 to 2026Enrolled400ConditionsPostoperative Pain, Postoperative Nausea, Opioid UseArmsAutonomic Neural Field Block
NCT07388953 narecruitingnot on this mapstarted 2026, after this paper: background citation

Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP): A Randomized, Controlled, Double-Blind Trial

TypeinterventionalSponsorFaculdade de Ciências Médicas de Minas GeraisRan2026 to 2027Enrolled140ConditionsColorectal Cancer, Colorectal Surgery, Anesthesia, Autonomic Nerve BlockArmsMinimally Invasive Left-Sided Colorectal Resection, BAPTAP (Peripheral Autonomic Blockade + TAP Block), Trocar/Incision Infiltration
NCT07655908 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Targeted Temporary In Situ Catheter Redosing of Autonomic Neural Blockade for Breakthrough Symptoms After Laparoscopic Sleeve Gastrectomy

TypeinterventionalSponsorUniversidad Simón BolívarRan2026 to 2027Enrolled30ConditionsPain, Acute Post-Operative, Nausea and Vomiting, PostoperativeArmsBupivacaine 0.5% and Dexamethasone via Temporary Catheter
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jorge DaesDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Clínicas Portoazul E Iberoamérica, Carrera 30 Corredor Universitario # 1-850, 081007, Puerto Colombia, Colombia. jorgedaez@gmail.com.ORCID 0000-0002-3125-6602
David J MorrellDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Penn State Health Milton S. Hershey Medical Center, 500 University Drive, PA, 17033, Hershey, USA.
Andrés HanssenDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Clínicas Portoazul E Iberoamérica, Carrera 30 Corredor Universitario # 1-850, 081007, Puerto Colombia, Colombia.
Melissa CaballeroDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Clínicas Portoazul E Iberoamérica, Carrera 30 Corredor Universitario # 1-850, 081007, Puerto Colombia, Colombia.
Elika LuqueDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Clínicas Portoazul E Iberoamérica, Carrera 30 Corredor Universitario # 1-850, 081007, Puerto Colombia, Colombia.
Rafael PantojaDivisiones de Anestesia Y de Cirugía, Universidad Simón Bolívar, Carrera 59 # 59-65, 080020, Barranquilla, Colombia.
Jorge LuquettaDepartment of Anesthesia, Clínicas Portoazul E Iberoamérica, Carrera 30 Corredor Universitario #1-850, 081007, Puerto Colombia, Colombia.
Eric M PauliDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Penn State Health Milton S. Hershey Medical Center, 500 University Drive, PA, 17033, Hershey, USA.
Penn State Milton S. Hershey Medical Center · USUniversidad Simón Bolívar · COUniversity of Atlántico · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVisceral pain (VP) following laparoscopic sleeve gastrectomy remains a substantial problem. VP is associated with autonomic symptoms, especially nausea and vomiting, and is unresponsive to traditional pain management algorithms aimed at alleviating somatic (incisional) pain. The present study was performed to evaluate the safety and effectiveness of laparoscopic paragastric autonomic neural blockade (PG-ANB) in managing the symptoms associated with VP following sleeve gastrectomy. STUDY

designThis prospective, double-blinded, randomized clinical trial involved patients undergoing laparoscopic sleeve gastrectomy at two high-volume institutions. The patients were randomized to laparoscopic transversus abdominis plane block with or without PG-ANB. The primary outcome was patient-reported pain scores assessed at 1, 8, and 24 h postoperatively. The secondary outcome measures were analgesic requirements, nausea, vomiting, hiccups, and hemodynamic changes immediately after PG-ANB and postoperatively.

resultsIn total, 145 patients (block group, n = 72; control group, n = 73) were included in the study. The heart rate and mean arterial pressure significantly decreased 10 min after PG-ANB. The visual analog scale score for pain was significantly lower in the PG-ANB than in the control group at 1 h postoperatively (p < 0.001) and 8 h postoperatively (p < 0.001). Vomiting, nausea, sialorrhea, and hiccups were significantly less prevalent in the PG-ANB group. Patients in the PG-ANB group received fewer cumulative doses of analgesics at 1 h postoperatively (p = 0.003) and 8 h postoperatively (p < 0.001). No differences between the groups were detected at 24 h (p = 0.298). No complications related to PG-ANB occurred.

conclusionPG-ANB safely and effectively reduces early VP, associated autonomic symptoms, and analgesic requirements after laparoscopic sleeve gastrectomy.

Indexed as

HiccupLaparoscopyObesity, MorbidVisceral PainAbdominal MusclesAnalgesicsAnalgesics, OpioidAnesthetics, LocalDouble-Blind MethodGastrectomyHumansNauseaPostoperative PainProspective StudiesVomitingAnalgesicsAnalgesics, OpioidAnesthetics, LocalAutonomicBlockMultimodal painOpioidsParagastricVisceral pain

Identifiers

PMID36050617
PMCPMC9613572
OpenAlexW4294120450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.