ArticleNature genetics2022
The genomic landscape of pediatric acute lymphoblastic leukemia.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06882057 (Chinese Children's Cancer Group-2025 Protocol for Newly Diagnosed Low Risk Childhood B-cell Acute Lymphoblastic Leukemia), which is not on this map. Cited by 259 papers.
0numbers the graph read from it
0cells of the map it votes in
259citing papers in PubMed
71.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT06882057 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation
Chinese Children's Cancer Group-2025 Protocol for Newly Diagnosed Low Risk Childhood B-cell Acute Lymphoblastic Leukemia
Who cites it
259 citing papers in PubMed, 369 citations in OpenAlex.
- Trial
- PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia.EMBO molecular medicine · 2026Article
- A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.Nature reviews. Cancer · 2026Review
- Plasticity under pressure: biology and detection of lineage switch in acute leukemia.Leukemia · 2026Review
- Association of Childhood Acute Leukemia With Autoimmune Diseases.International journal of cancer · 2026Article
- Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy.Leukemia · 2026Article
- Measurable residual disease detected by next-generation sequencing in T-cell acute lymphoblastic leukemia.Nature communications · 2026Article
- Pitfalls and Challenges in the Detection of ZNF384 Rearrangements by Fluorescence in Situ Hybridization.Genes, chromosomes & cancer · 2026Article
- Article
- Selective sensitivity of Ph-like B-cell acute lymphoblastic leukemia to BRG1 inhibition identifies a therapeutic vulnerability.Leukemia · 2026Article
- Biological and pathogenic roles of major genes harbored in intrachromosomal amplification of chromosome 21 in childhood acute lymphoblastic leukemia (Review).Oncology letters · 2026Review
- Article
- clinTALL: machine learning-driven multimodal subtype classification and treatment outcome prediction in pediatric T-ALL.Genome medicine · 2026Article
- The clinical relevance of RAS pathway gene mutations in childhood B-cell acute lymphoblastic leukemia.Annals of hematology · 2026Article
- Personalized reference genome-based pipeline reveals comprehensive haplotype-resolved views of cancer genomes.bioRxiv : the preprint server for biology · 2026Article
- Clinical features and initial treatment outcomes of pediatric B-cell acute lymphoblastic leukemia with P2RY8::CRLF2 fusion positivity: a case series.Translational pediatrics · 2026Article
- Chromosome 15q deletions confer inferior outcomes among children with ETV6::RUNX1 B-cell acute lymphoblastic leukemia.Blood advances · 2026Article
- Hyperleukocytosis and outcomes in pediatric B-cell acute lymphoblastic leukemia: A report from the REDIAL Consortium.medRxiv : the preprint server for health sciences · 2026Article
- A Greek Case-Control Replication Study ofGenes · 2026Article
- Deep learning based individualized cross-platform molecular subtype classification of B-lineage acute lymphoblastic leukemia.NPJ precision oncology · 2026Article
199 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
77 authors at 20 institutions in 1 country.
Samuel W Brady *Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-5518-7800
Kathryn G Roberts *Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-7626-4043
Zhaohui GuDepartment of Computational and Quantitative Medicine & Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-1581-1327
Lei ShiDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stanley PoundsDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-9167-2114
Deqing PeiDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cheng ChengDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yunfeng DaiDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-3961-4766
Meenakshi DevidasDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1099-3478
Chunxu QuDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ashley N HillDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Debbie Payne-TurnerDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xiaotu MaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6233-2145
Ilaria IacobucciDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-2008-1365
Pradyuamna BaviskarDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-1110-5695
Lei WeiDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1881-8666
Sasi ArunachalamDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kohei HagiwaraDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yanling LiuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Diane A FlaschDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yu LiuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-8928-2558
Matthew ParkerDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-2999-3870
Xiaolong ChenDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-8283-0582
Abdelrahman H ElsayedDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Omkar PathakDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yongjin LiDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yiping FanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
J Robert MichaelDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Michael RuschDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-5363-1848
Mark R WilkinsonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Scott FoyDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Dale J HedgesDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Scott NewmanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xin ZhouDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jian WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Colleen ReillyDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Edgar SiosonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-7540-8516
Stephen V RiceDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-3489-8459
Victor Pastor LoyolaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Gang WuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1678-5864
Evadnie RampersaudCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shalini C ReshmiInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Julie Gastier-FosterDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Jaime M Guidry AuvilOffice of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Patee GesuwanOffice of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Malcolm A SmithCancer Therapeutics Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9880-9876
Naomi WinickDepartment of Pediatric Hematology Oncology and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-6636-3870
Andrew J CarrollDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0001-9844-730X
Nyla A HeeremaThe Ohio State University, Columbus, OH, USA.
Richard C HarveyDepartment of Pathology, University of New Mexico Cancer Center, Albuquerque, NM, USA.
Cheryl L WillmanMayo Clinical Comprehensive Cancer Center, Rochester, MN, USA.
Eric LarsenDepartment of Pediatrics, Maine Children's Cancer Program, Scarborough, ME, USA.
Elizabeth A RaetzDepartment of Pediatrics and Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA.
Michael J BorowitzDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Brent L WoodDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
William L CarrollDepartment of Pediatrics and Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1550-4167
Patrick A Zweidler-McKayImmunoGen, Inc., Waltham, MA, USA.
Karen R RabinDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Leonard A MattanoHARP Pharma Consulting, Mystic, CT, USA.
Kelly W MaloneyDepartment of Pediatrics and Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Stuart S WinterChildren's Minnesota Research Institute and Cancer and Blood Disorders Program, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-3583-7727
Michael J BurkeDivision of Pediatric Hematology-Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-6626-2773
Wanda SalzerUniformed Services University, School of Medicine, Bethesda, MD, USA.
Kimberly P DunsmoreDepartment of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Anne L AngiolilloChildren's National Medical Center, Washington, DC, USA.
Kristine R CrewsDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-7558-558X
James R DowningDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sima JehaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ching-Hon PuiDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-0303-5658
William E EvansDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-9333-5322
Jun J YangDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-0770-9659
Mary V RellingDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-3720-9591
Daniela S GerhardOffice of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mignon L LohDepartment of Pediatrics, Benioff Children's Hospital and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Stephen P HungerDepartment of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Hungers@chop.edu.ORCID http://orcid.org/0000-0002-5492-3957
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. jinghui.zhang@stjude.org.ORCID http://orcid.org/0000-0003-3350-9682
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.ORCID http://orcid.org/0000-0002-1871-1850
St. Jude Children's Research Hospital · USNational Institutes of Health · USBaylor College of Medicine · USNYU Langone Health · USChildren's Hospital Colorado · USChildren's Hospital of Philadelphia · USChildren's Minnesota · USChildren's National · USCity of Hope · USImmunoGen (United States) · USJohns Hopkins University · USMayo Clinic · USMedical College of Wisconsin · USNationwide Children's Hospital · USNew England Cancer Specialists · USThe Ohio State University · USThe University of Texas Southwestern Medical Center · USUniformed Services University of the Health Sciences · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LOH, MIGNON LEE-CHEUN, RELLING, MARY V · 2015 to 2019
$15.1MTranslating genomic discoveries to improved outcomes for high risk acute leukemiaR35CA197695 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2017 to 2026
$11.4MDiscovery of Somatic Noncoding Variants that Serve as Drivers in Pediatric CancersR01CA216391 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZHANG, JINGHUI · 2018 to 2022
$2.8MCharacterization of novel subtypes in B progenitor acute lymphoblastic leukemiaR00CA241297 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI GU, ZHAOHUI · 2020 to 2022
$747kNCI NIH HHS P30 CA021765NCI NIH HHS R00 CA241297NCI NIH HHS R01 CA216391NCI NIH HHS R35 CA197695NIGMS NIH HHS P50 GM115279
Abstract
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low mutation burden, ALL cases harbor a median of four putative somatic driver alterations per sample, with 376 putative driver genes identified varying in prevalence across ALL subtypes. Most samples harbor at least one rare gene alteration, including 70 putative cancer driver genes associated with ubiquitination, SUMOylation, noncoding transcripts and other functions. In hyperdiploid B-ALL, chromosomal gains are acquired early and synchronously before ultraviolet-induced mutation. By contrast, ultraviolet-induced mutations precede chromosomal gains in B-ALL cases with intrachromosomal amplification of chromosome 21. We also demonstrate the prognostic significance of genetic alterations within subtypes. Intriguingly, DUX4- and KMT2A-rearranged subtypes separate into CEBPA/FLT3- or NFATC4-expressing subgroups with potential clinical implications. Together, these results deepen understanding of the ALL genomic landscape and associated outcomes.
Indexed as
Precursor Cell Lymphoblastic Leukemia-LymphomaChildChromosome AberrationsExomeGenomicsHumansMutation
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Registered trials
NCT06882057ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.