ArticleNature chemical biology2022
Horizontal gene transfer enables programmable gene stability in synthetic microbiota.
Article in Nature chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Resilience of recombinant antibiotic resistance gene-containing plasmids against common cell culture disposal methods.Cell reports methods · 2026Article
- Information storage across a microbial community using universal RNA barcoding.Nature biotechnology · 2026Article
- Longitudinal gut microbiota tracking reveals the dynamics of horizontal gene transfer.Nature communications · 2025Article
- Dynamical memory underlies prolonged plasmid persistence after transient antibiotic treatment.bioRxiv : the preprint server for biology · 2025Article
- Why cellular computations challenge our design principles.Seminars in cell & developmental biology · 2025Review
- Linear scaling reveals low-dimensional structure in observable microbial dynamics.bioRxiv : the preprint server for biology · 2025Article
- Transposon-plasmid nesting enables fast response to fluctuating environments.bioRxiv : the preprint server for biology · 2025Article
- The Abundance of Viroid-Like RNA Obelisk-S.s in Streptococcus sanguinis SK36 May Suffice for Evolutionary Persistence.Journal of molecular evolution · 2025Article
- Population-level amplification of gene regulation by programmable gene transfer.Nature chemical biology · 2025Article
- An Exploration of the Relationship Between Gut Virome and Cardiovascular Disease: A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- Rhizosphere-triggered viral lysogeny mediates microbial metabolic reprogramming to enhance arsenic oxidation.Nature communications · 2025Article
- A predatory gene drive for targeted control of self-transmissible plasmids.Science advances · 2025Article
- Antibiotic-mediated microbial community restructuring is dictated by variability in antibiotic-induced lysis rates and population interactions.Nature communications · 2025Article
- A bayesian approach for parameterizing and predicting plasmid conjugation dynamics.Scientific reports · 2025Article
- The metabolic burden associated with plasmid acquisition: An assessment of the unrecognized benefits to host cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- The evolution of autonomy from two cooperative specialists in fluctuating environments.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Microbial diversity and ecological complexity emerging from environmental variation and horizontal gene transfer in a simple mathematical model.BMC biology · 2024Article
- Tuning interdomain conjugation to enablemSystems · 2024Article
- Programming Dynamic Division of Labor Using Horizontal Gene Transfer.ACS synthetic biology · 2024Article
- The impact of phage and phage resistance on microbial community dynamics.PLoS biology · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The functions of many microbial communities exhibit remarkable stability despite fluctuations in the compositions of these communities. To date, a mechanistic understanding of this function-composition decoupling is lacking. Statistical mechanisms have been commonly hypothesized to explain such decoupling. Here, we proposed that dynamic mechanisms, mediated by horizontal gene transfer (HGT), also enable the independence of functions from the compositions of microbial communities. We combined theoretical analysis with numerical simulations to illustrate that HGT rates can determine the stability of gene abundance in microbial communities. We further validated these predictions using engineered microbial consortia of different complexities transferring one or more than a dozen clinically isolated plasmids, as well as through the reanalysis of data from the literature. Our results demonstrate a generalizable strategy to program the gene stability of microbial communities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.