ArticleNature communications2022
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
7.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants.Journal of the American Heart Association · 2024Pooled it
- Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.Nature communications · 2024Pooled it
- Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review.PharmacogenomicsPooled it
- Integrated Genomic and Transcriptomic Analysis Reveals the Genetic Basis and Causal Association Between Obesity and Atrial Fibrillation.Diabetes, obesity & metabolism · 2026Article
- Multi-trait GWAS reveals divergent local and polygenic architecture of cardiovascular traits across African and European ancestries in the UK Biobank.Communications biology · 2026Article
- A self-supervised electrocardiogram foundation model for empowering cardiovascular disease prediction and genetic factor discovery.Nature communications · 2026Article
- Genome-wide association study-identified novel genetic loci for QT interval in Taiwan: implications for population-specific arrhythmia risk.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Empowering genetic discoveries and cardiovascular risk assessment by predicting electrocardiograms from genotype.NPJ digital medicine · 2026Article
- Polygenic risk modulates myocardial repolarization and T-wave geometry in congenital long-QT syndrome type 1: evidence from digital ECG phenotyping.Frontiers in cardiovascular medicine · 2026Article
- The Utility of Genome-Wide Association Studies in Inherited Arrhythmias and Cardiomyopathies.Genes · 2025Review
- An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy.Nature genetics · 2025Article
- Deep representation learning of electrocardiogram reveals biological insights in cardiac phenotypes and cardiovascular diseases.iScience · 2025Article
- Genomic and molecular evidence that the LncRNA DSP-AS1 modulates desmoplakin expression.Human genetics · 2025Article
- Uncovering causal gene-tissue pairs and variants through a multivariate TWAS controlling for infinitesimal effects.Nature communications · 2025Article
- Phenotypic expression of rare progressive cardiac conduction disease variants in the general population.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Identification and Functional Assessment of Candidate CausalCirculation. Genomic and precision medicine · 2025Article
- Large-Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital-Based Controls and Moxifloxacin-Treated Cases.Clinical and translational science · 2025Article
- Massively parallel reporter assays identify functional enhancer variants at QT interval GWAS loci.bioRxiv : the preprint server for biology · 2025Article
- Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants.Cell genomics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
166 authors at 20 institutions in 15 countries.
William J YoungWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0002-9831-6817
Najim LahrouchiAmsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Aaron IsaacsDeptartment of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0001-5037-4834
ThuyVy DuongMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Luisa FocoEurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.ORCID 0000-0002-6694-3322
Farah AhmedWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8509-148X
Reem SalmanWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
Raymond NoordamDepartment of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-7801-809X
Jan-Walter BenjaminsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.ORCID 0000-0002-5701-0539
Jeffrey HaesslerPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID 0000-0002-7200-5455
Linda RepettoCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
Maria Pina ConcasInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID 0000-0003-3598-2537
Marten E van den BergDepartment of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.
Stefan WeissDZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.ORCID 0000-0002-3553-4315
Antoine R BaldassariDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
James P CookDepartment of Health Data Science, University of Liverpool, Liverpool, UK.
Daniel S EvansCalifornia Pacific Medical Center, Research Institute, San Francisco, CA, USA.
Rebecca FreudlingDepartment of Cardiology, University Hospital, LMU Munich, Munich, Germany.
Oliver HinesGenetics Research Centre, St George's University of London, London, UK.
Jonas L IsaksenLaboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3227-1131
Honghuang LinNational Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID 0000-0003-3043-3942
Hao MeiDepartment of Data Science, University of Mississippi Medical Center, Jackson, USA.
Arden MoscatiThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Casia NursyifaNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yong QianTranslational Gerontology Branch, National Institute on Aging, National Institute of Health, Baltimore, US.
Anne RichmondMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Carolina RoselliUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.ORCID 0000-0001-5267-6756
Kathleen A RyanDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1158-8455
Eduardo Tarazona-SantosDepartment of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte/Minas Gerais, Brazil.
Sébastien ThériaultPopulation Health Research Institute, McMaster University, Hamilton, Canada.
Stefan van DuijvenbodenWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
Helen R WarrenWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0003-0511-1386
Jie YaoInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Dania RazaWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
Stefanie AeschbacherCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Gustav AhlbergLaboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-2225-8323
Laura AndreasenLaboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-4732-4921
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3409-1110
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Archie CampbellUsher Institute, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.ORCID 0000-0003-0198-5078
Eulalia CatamoInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Massimiliano CoccaInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID 0000-0002-1127-7596
Michael J CutlerIntermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.ORCID 0000-0001-9498-7472
Dawood DarbarDepartment of Medicine, University of Illinois at Chicago, Chicago, USA.ORCID 0000-0002-4103-5977
Alessandro De GrandiEurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.
Antonio De LucaCardiothoracovascular Department, ASUGI, University of Trieste, Trieste, Italy.
Jun DingTranslational Gerontology Branch, National Institute on Aging, National Institute of Health, Baltimore, US.
Christina EllervikDepartment of Data and Data Support, Region Zealand, 4180, Sorø, Denmark.ORCID 0000-0002-3088-4375
Patrick T EllinorCardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.ORCID 0000-0002-2067-0533
Stephan B FelixDZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.
Philippe FroguelDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.ORCID 0000-0003-2972-0784
Christian FuchsbergerEurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.
Martin GögeleEurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.ORCID 0000-0003-4785-4348
Claus GraffDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-6380-1735
Xiuqing GuoInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-5264-5068
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Susan R HeckbertCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7100-512X
Paul L HuangCardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA.
Heikki V HuikuriResearch Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University Hospital, Tampere, Finland.
M Arfan IkramDepartment of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-0372-8585
Rebecca D JacksonCenter for Clinical and Translational Science, Ohio State Medical Center, Columbus, OH, USA.
Juhani JunttilaResearch Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland.
Maryam KavousiDepartment of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-5976-6519
Jan A KorsDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, NL, The Netherlands.
Thiago P LealDepartment of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte/Minas Gerais, Brazil.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7038-1844
Henry J LinInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0001-6771-0486
Lars LindDeptartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.ORCID 0000-0002-0994-0184
Simin LiuCenter for Global Cardiometabolic Health, Departments of Epidemiology, Medicine and Surgery, Brown University, Providence, USA.ORCID 0000-0003-2098-3844
Peter W MacFarlaneInstitute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-2167-7470
Thomas MeitingerInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-8838-8403
Massimo MezzavillaInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID 0000-0002-9000-4595
Pashupati P MishraDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Rebecca N MitchellMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nina MononenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
May E MontasserDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9558-5456
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-6381-4296
Matthias NauckDZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.ORCID 0000-0002-6678-7964
Victor NauffalCardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.
Pau NavarroMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0001-5576-8584
Kjell NikusDepartment of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
Guillaume ParePopulation Health Research Institute, McMaster University, Hamilton, Canada.
Kristen K PattonCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Giulia PelliccioneInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Alan PittmanGenetics Research Centre, St George's University of London, London, UK.ORCID 0000-0002-8112-2987
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0003-1249-6106
Peter P PramstallerEurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.ORCID 0000-0002-9831-8302
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-5266-8465
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Alexander P ReinerDepartment of Epidemiology/University of Washington, Seattle, WA, USA.ORCID 0000-0002-1427-4470
Antonio Luiz P RibeiroDepartment of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil, Belo Horizonte, Minas Gerais, Brazil.ORCID 0000-0002-2740-0042
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3071-7278
Lorenz RischLabormedizinisches zentrum Dr. Risch, Vaduz, Liechtenstein.ORCID 0000-0003-2692-6699
David SchlessingerLaboratory of Genetics and Genomics, National Institute on Aging, National Institute of Health, Baltimore, US.
Ulrich SchottenDeptartment of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands.
Claudia SchurmannThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-4158-9192
Xia ShenCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0003-4390-1979
M Benjamin ShoemakerDepartment of Medicine, Division of Cardiovascular Medicine, Arrhythmia Section, Vanderbilt University Medical Center, Nashville, TN, USA.
Gianfranco SinagraCardiothoracovascular Department, ASUGI, University of Trieste, Trieste, Italy.ORCID 0000-0003-2700-8478
Moritz F SinnerDepartment of Cardiology, University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-6660-796X
Elsayed Z SolimanEpidemiological Cardiology Research Center EPICARE, Wake Forest School of Medicine, Winston Salem, USA.ORCID 0000-0001-5632-8150
Monika StollMaastricht Center for Systems Biology MaCSBio, Maastricht University, Maastricht, The Netherlands.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Kirill TarasovLaboratory of Cardiovascular Sciences, National Institute on Aging, National Institute of Health, Baltimore, US.ORCID 0000-0001-7799-4670
Kent D TaylorInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Andrew TinkerWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0001-7703-4151
Stella TrompetDepartment of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-5006-0528
André UitterlindenInternal Medicine, Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0002-7276-3387
Uwe VölkerDZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.
Henry VölzkeDZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.
Melanie WaldenbergerDZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany.ORCID 0000-0003-0583-5093
Lu-Chen WengCardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.ORCID 0000-0003-1475-4930
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.ORCID 0000-0003-4843-3641
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA.
Christy L AveryDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.ORCID 0000-0002-1044-8162
David ConenPopulation Health Research Institute, McMaster University, Hamilton, Canada.
Adolfo CorreaDepartments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, USA.ORCID 0000-0002-9501-600X
Francesco CuccaInstitute of Genetic and Biomedical Rsearch, Italian National Research Council, Monserrato, Italy.
Marcus DörrDZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.ORCID 0000-0001-7471-475X
Sina A GharibCenter for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA.
Giorgia GirottoInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID 0000-0003-4507-6589
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5526-1070
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0002-9405-9550
Yalda JamshidiGenetics Research Centre, St George's University of London, London, UK.ORCID 0000-0003-0151-6482
Marjo-Riitta JärvelinCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-2149-0630
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-3246-8359
Stefan KääbDepartment of Cardiology, University Hospital, LMU Munich, Munich, Germany.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Jørgen K KantersLaboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3267-4910
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-7986-8560
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID 0000-0002-2555-4427
Maria Fernanda Lima-CostaInstituto René Rachou, fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Yongmei LiuDepartment of Medicine, Duke University, Durham, NC, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8532-5087
Steven A LubitzCardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.ORCID 0000-0002-9599-4866
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Andrew P MorrisDepartment of Health Data Science, University of Liverpool, Liverpool, UK.ORCID 0000-0002-6805-6014
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Morten Salling OlesenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-9477-5322
Michele OriniBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.ORCID 0000-0001-5773-0344
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Cristian PattaroEurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.ORCID 0000-0002-4119-0109
Annette PetersInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0001-6645-0985
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7278-2190
Jerome I RotterInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Bruno StrickerDepartment of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.
Pim van der HarstUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.ORCID 0000-0002-2713-686X
Cornelia M van DuijnNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-2374-9204
Niek VerweijUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.ORCID 0000-0002-4303-7685
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0001-5751-9178
Dan E ArkingMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Julia RamirezWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID 0000-0003-4130-5866
Pier D LambiaseBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Borbala MifsudWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
Christopher Newton-ChehProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. cnewtoncheh@mgh.harvard.edu.ORCID 0000-0002-3001-9111
Patricia B MunroeWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.ORCID 0000-0002-4176-2947
University of Washington · USUniversity of Copenhagen · DKQueen Mary University of London · GBBroad Institute · USErasmus MC · NLTampere University · FIEurac Research · ITUniversitätsmedizin Greifswald · DEIRCCS Materno Infantile Burlo Garofolo · ITHelmholtz Zentrum München · DELeiden University Medical Center · NLNational Institute on Aging · USUniversity of North Carolina at Chapel Hill · USWestern General Hospital · GBJohns Hopkins University · USMaastricht University · NLOulu University Hospital · FIPopulation Health Research Institute · CASt Bartholomew's Hospital · GBSt George's, University of London · GB
Funding
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI JONES, ALAN E · 2016 to 2025
$38.2MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MTRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MHispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8MIntegrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3MGenetic Epidemiology of Causal Variants across the Life Course Phase II (CALiCo IU01HG007416 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NORTH, KARI E. · 2013 to 2017
$3.9MGenomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3MCharacterizing pleiotropy in cardiometabolic phenotypes among diverse populations - Admin SupplR01HL142825 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH · 2019 to 2023
$3.3MAFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1MInfluence of genetic variation on QT prolongation over the lifecourse and as a cardiotoxic drug responseR01HL143070 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEWTON-CHEH, CHRISTOPHER HOLMES · 2018 to 2021
$3.0MResilience to obesity in carriers of monogenic obesity mutations - a study on the underlying mechanismsR01DK124097 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LOOS, RUTH JF · 2020 to 2023
$2.9MAmerican Heart Association-American Stroke Association 19SFRN34830063Department of HealthMedical Research Council MC_UU_00007/10Medical Research Council MR/N025083/1Medical Research Council MR/R010676/1Medical Research Council MR/R017468/1Medical Research Council MR/S019669/1NHGRI NIH HHS U01 HG007416NHLBI NIH HHS K23 HL127704NHLBI NIH HHS K24 HL105780NHLBI NIH HHS K24 HL148521NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL138737NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL141989NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL142825NHLBI NIH HHS R01 HL143070NHLBI NIH HHS T32 HL007604NHLBI NIH HHS T32 HL139439NIA NIH HHS U01 AG068221NIA NIH HHS U24 AG051129NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01 DK110113NIDDK NIH HHS R01 DK124097NIGMS NIH HHS U54 GM115428
Abstract
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.
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Arrhythmias, CardiacElectrocardiographyDeath, Sudden, CardiacGenetic TestingHumansMale
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.