Evidence map›Paper›PMID 36050231›Full record

ArticleUltrasound in medicine & biology2022

Acoustic Detection of Retained Perfluoropropane Droplets Within the Developing Myocardial Infarct Zone.

Ping Zeng, Cheng Chen, John Lof, Elizabeth Stolze, Shouqiang Li, Xucai Chen, John Pacella, Flordeliza S Villanueva, Terry Matsunaga, E Carr Everbach and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results in Selective Bioactivation of the Risk Area.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ping ZengDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Cheng ChenCenter for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John LofDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Elizabeth StolzeDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Shouqiang LiDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA; Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xucai ChenCenter for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John PacellaCenter for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Flordeliza S VillanuevaCenter for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Terry MatsunagaDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona, USA; Department of Medical Imaging, University of Arizona, Tucson, Arizona, USA.
E Carr EverbachSwarthmore College, Swarthmore, Pennsylvania, USA.
Hongwen FeiDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Feng XieDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Thomas PorterDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA. Electronic address: trporter@unmc.edu.

Funding

Scar Detection and Treatment with Droplet ActivationR01HL146489 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PORTER, THOMAS R · 2020 to 2023
$3.0M
NHLBI NIH HHS R01 HL146489
6 · The paper itself

Abstract

Perfluoropropane droplets (PDs) cross endothelial barriers and can be acoustically activated for selective myocardial extravascular enhancement following intravenous injection (IVI). Our objective was to determine how to optimally activate extravascular PDs for transthoracic ultrasound-enhanced delineation of a developing scar zone (DSZ). Ultrafast-frame-rate microscopy was conducted to determine the effect of pulse sequence on the threshold of bubble formation from PDs. In vitro studies were subsequently performed at different flow rates to determine acoustic activation and inertial cavitation thresholds for a PD infusion using multipulse fundamental non-linear or single-pulse harmonic imaging. IVIs of PDs were given in 9 rats and 10 pigs following prolonged left anterior descending ischemia to detect and quantify PD kinetics within the DSZ. A multipulse sequence had a lower myocardial index threshold for acoustic activation by ultrafast-frame-rate microscopy. Acoustic activation was observed at a myocardial index ≥0.4 below the inertial cavitation threshold for both pulse sequences. In rats, confocal microscopy and serial acoustic activation imaging detected higher droplet presence (relative to remote regions) within the DSZ at 3 min post-IVI. Transthoracic high-mechanical-index impulses with fundamental non-linear imaging in pigs at this time post-IVI resulted in selective contrast enhancement within the DSZ.

Indexed as

FluorocarbonsMyocardial InfarctionAcousticsAnimalsContrast MediaMicrobubblesRatsSwineContrast MediaFluorocarbonsperflutrenAcoustic activationDropletsImagingInertial cavitationMicrobubblesMyocardial ischemiaPerfluoropropaneStable cavitationTransthoracic

Identifiers

PMID36050231
PMCPMC9547398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.