Evidence map›Paper›PMID 36049665›Full record

ArticleOsteoarthritis and cartilage2022

Multi-vendor multi-site quantitative MRI analysis of cartilage degeneration 10 Years after anterior cruciate ligament reconstruction: MOON-MRI protocol and preliminary results.

D Xie, J Murray, R Lartey, S Gaj, J Kim, M Li, B L Eck, C S Winalski, F Altahawi, M H Jones and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  3. Article
  4. Article
  5. Bilateral waveform analysis of gait biomechanics presurgery to 12 months following ACL reconstruction compared to controls.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

D XieProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: xdx1024@csu.edu.cn.
J MurrayProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: murrayj8@ccf.org.
R LarteyProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: larteyr@ccf.org.
S GajProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: gajs@ccf.org.
J KimProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: kimj14@ccf.org.
M LiProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: lim3@ccf.org.
B L EckProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: eckb@ccf.org.
C S WinalskiProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: winalsc@ccf.org.
F AltahawiProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: altahaf@ccf.org.
M H JonesDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: mhjones@bwh.harvard.edu.
N A ObuchowskiProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: obuchon@ccf.org.
L J HustonDepartment of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: laura.huston@vanderbilt.edu.
K D HarkinsDepartments of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: kevin.harkins@vanderbilt.edu.
H T FrielMR Clinical Science, Philips Healthcare, Highland Heights, OH, USA. Electronic address: harry.friel@philips.com.
B M DamonDepartments of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: Bruce.Damon@carle.com.
M V KnoppWright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University, Columbus, OH, USA. Electronic address: knopp.16@osu.edu.
C C KaedingDepartment of Orthopaedic Surgery, The Ohio State University, Columbus, OH, USA. Electronic address: christopher.kaeding@osumc.edu.
K P SpindlerProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA. Electronic address: spindlk@ccf.org.
X LiProgram of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: lix6@ccf.org.
Cleveland Clinic · USVanderbilt University Medical Center · USThe Ohio State University · USBrigham and Women's Hospital · USPhilips (Finland) · FI

Funding

Prognosis and Predictors of ACL Reconstruction: A Multicenter Cohort StudyR01AR053684 · NIAMS · VANDERBILT UNIVERSITY · PI SPINDLER, KURT PAUL · 2006 to 2020
$8.3M
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRIR01AR075422 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI LI, XIAOJUAN, SPINDLER, KURT PAUL · 2019 to 2023
$4.6M
Meniscus status and activity level after ACLK23AR066133 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI JONES, MORGAN HERANCOURT · 2015 to 2019
$745k
NIAMS NIH HHS K23 AR066133NIAMS NIH HHS R01 AR053684NIAMS NIH HHS R01 AR075422
6 · The paper itself

Abstract

objectiveTo describe the protocol of a multi-vendor, multi-site quantitative MRI study for knee post-traumatic osteoarthritis (PTOA), and to present preliminary results of cartilage degeneration using MR T

designThis study involves three sites and two MR platforms. The patients are from a nested cohort (termed as Onsite cohort) within the Multicenter Orthopaedic Outcomes Network (MOON) cohort 10 years after ACLR. Phantoms and controls were scanned for evaluating reproducibility. Cartilage was automatically segmented, and T

resultsSixty-eight ACL-reconstructed patients and 20 healthy controls were included. In phantoms, the intra-site coefficients of variation (CVs) of repeated scans ranged 1.8-2.1% for T

conclusionA platform and workflow with rigorous quality control has been established for a multi-vendor multi-site quantitative MRI study in evaluating PTOA 10 years after ACLR. Our preliminary report suggests significant cartilage matrix changes in both operated and contralateral knees compared with healthy control knees.

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionCartilage, ArticularOrthopedicsOsteoarthritisHumansKnee JointMagnetic Resonance ImagingMulticenter Studies as TopicReproducibility of ResultsACL ReconstructionCartilage degenerationMRIT(1ρ)T(2)

Identifiers

PMID36049665
PMCPMC9671830
OpenAlexW4293521992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.