ArticleClinical immunology (Orlando, Fla.)2022
Fecal immunoglobulin A (IgA) and its subclasses in systemic lupus erythematosus patients are nuclear antigen reactive and this feature correlates with gut permeability marker levels.
Article in Clinical immunology (Orlando, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Intestinal and Blood-Brain Barrier Dysfunction in Lupus: Emerging Mechanisms and Modulation by Cinnamon.Molecules (Basel, Switzerland) · 2026Review
- Serum IgA autoantibody profiling in systemic lupus erythematosus reveals associations with disease phenotypes.RMD open · 2026Article
- Clinical characteristics and risk factors of protein-losing enteropathy: a retrospective study.Frontiers in immunology · 2026Article
- Article
- Increased Intestinal Permeability and Articular Involvement in Systemic Lupus Erythematosus Patients-A Mutually Exclusive Relationship?Current issues in molecular biology · 2025Article
- Low-dose rituximab in lupus enteritis: a comparative study on its efficacy in modulating mucosal immunity and reducing inflammation.Arthritis research & therapy · 2025Article
- Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus.Journal of translational medicine · 2025Article
- Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways.Inflammatory bowel diseases · 2025Review
- Alteration in gut microbiota accompanied by increased intestinal permeability and Tfh/Tfr imbalance in patients with active SLE.Frontiers in cellular and infection microbiology · 2025Article
- Diagnostic study of serum claudin-3 and zonulin for intestinal barrier dysfunction after abdominal surgery.Frontiers in medicine · 2025Article
- Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes.Science translational medicine · 2024Article
- Intestinal permeability correlates with disease activity and DNA methylation changes in lupus patients.Clinical immunology (Orlando, Fla.) · 2024Article
- Lupus IgA1 autoantibodies synergize with IgG to enhance pDC responses to RNA-containing immune complexes.bioRxiv : the preprint server for biology · 2024Article
- Article
- Loss of Gut Barrier Integrity In Lupus.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Systemic lupus erythematosus (SLE) is characterized by the production of anti-nuclear autoantibodies. Here, for the first time, we show that the abundances of gut permeability marker Zonulin and IgA1- and IgA2- subclasses are significantly higher in the fecal samples of SLE patients compared to HCs. Importantly, IgA-total, and IgA1- and IgA2-subclasses from SLE patients showed higher nAg reactivity titers. Notably, we found that not only the nuclear antigen (nAg) reactive fecal IgA1:IgA2 ratio is higher in SLE patients, but also the abundance and nAg reactivity of fecal IgA and subclasses, IgA1 particularly, correlate with the fecal levels of Zonulin, which is produced primarily in the small intestine. These observations that higher amounts of nAg-reactive IgA and gut permeability marker are produced, particularly, in the proximal gut suggest a compromised epithelial barrier function and pro-inflammatory characteristics of small intestine in SLE patients.
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