ArticleCurrent biology : CB2022
Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06484088 (Characterizing the Brain Circuitry and Neural Activity Mediating Frustration), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing the Brain Circuitry and Neural Activity Mediating Frustration
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior.Cell reports · 2026Article
- Asymmetric lateral habenula function and peripheral neural mechanisms in regulating itch-evoked scratching.Current biology : CB · 2025Article
- Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors.Nature communications · 2025Article
- Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.Research square · 2025Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.bioRxiv : the preprint server for biology · 2024Article
- Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility.Neuron · 2024Article
- A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The role of the mediodorsal thalamus in chemosensory preference and consummatory behavior in rats.Chemical senses · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Survival requires both the ability to persistently pursue goals and the ability to determine when it is time to stop, an adaptive balance of perseverance and disengagement. Neural activity in the lateral habenula (LHb) has been linked to negative valence, but its role in regulating the balance between engaged reward seeking and disengaged behavioral states remains unclear. Here, we show that LHb neural activity is tonically elevated during minutes-long periods of disengagement from reward-seeking behavior, both when due to repeated reward omission (negative valence) and when sufficient reward has been consumed (positive valence). Furthermore, we show that LHb inhibition extends ongoing reward-seeking behavioral states but does not prompt task re-engagement. We find no evidence for similar tonic activity changes in ventral tegmental area dopamine neurons. Our findings support a framework in which tonic activity in LHb neurons suppresses engagement in reward-seeking behavior in response to both negatively and positively valenced factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.