Evidence map›Paper›PMID 36049222›Full record

ArticleAdvanced healthcare materials2022

Ultrasound-Enhanced Antibacterial Activity of Polymeric Nanoparticles for Eradicating Bacterial Biofilms.

Sanjana Gopalakrishnan, Aarohi Gupta, Jessa M V Makabenta, Jungmi Park, John J Amante, Aritra Nath Chattopadhyay, Dorcas Matuwana, Cathal J Kearney, Vincent M Rotello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  16. MethodsX · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sanjana GopalakrishnanDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.ORCID 0000-0003-0590-0545
Aarohi GuptaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.ORCID 0000-0003-1303-1159
Jessa M V MakabentaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.ORCID 0000-0002-2062-7914
Jungmi ParkDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.
John J AmanteDepartment of Biomedical Engineering, University of Massachusetts Amherst, 240 Thatcher Road, Amherst, MA, 01003, USA.ORCID 0000-0002-8777-6551
Aritra Nath ChattopadhyayDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.ORCID 0000-0001-8658-6919
Dorcas MatuwanaDepartment of Biomedical Engineering, University of Massachusetts Amherst, 240 Thatcher Road, Amherst, MA, 01003, USA.
Cathal J KearneyDepartment of Biomedical Engineering, University of Massachusetts Amherst, 240 Thatcher Road, Amherst, MA, 01003, USA.ORCID 0000-0002-9514-6517
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.ORCID 0000-0002-5184-5439

Funding

Engineered Polymer Nanoemulsions for Treatment of Wound Biofilm InfectionsR01AI134770 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Robin Patel, VINCENT M. ROTELLO · 2018 to 2026
$3.5M
NIAID NIH HHS R01 AI134770
6 · The paper itself

Abstract

Bacterial biofilms are a major healthcare concern resulting in refractory conditions such as chronic wounds, implant infections and failure, and multidrug-resistant infections. Aggressive and invasive strategies are employed to cure biofilm infections but are prone to long and expensive treatments, adverse side-effects, and low patient compliance. Recent strategies such as ultrasound-based therapies and antimicrobial nanomaterials have shown some promise in the effective eradication of biofilms. However, maximizing therapeutic effect while minimizing healthy tissue damage is a key challenge that needs to be addressed. Here a combination treatment involving ultrasound and antimicrobial polymeric nanoparticles (PNPs) that synergistically eradicate bacterial biofilms is reported. Ultrasound treatment rapidly disrupts biofilms and increases penetration of antimicrobial PNPs thereby enhancing their antimicrobial activity. This results in superior biofilm toxicity, while allowing for a two- to sixfold reduction in both the concentration of PNPs as well as the duration of ultrasound. Furthermore, that this reduction minimizes cytotoxicity toward fibroblast cells, while resulting in a 100- to 1000-fold reduction in bacterial concentration, is demonstrated.

Indexed as

Anti-Infective AgentsNanoparticlesAnti-Bacterial AgentsBacteriaBiofilmsHumansMicrobial Sensitivity TestsPolymersAnti-Bacterial AgentsAnti-Infective AgentsPolymersbiofilm disruptionbiofilm eradicationMRSA biofilm treatmentpolymeric nanoparticlessynergistic antimicrobial therapyultrasound treatment

Identifiers

PMID36049222
PMCPMC9633556

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.