Evidence map›Paper›PMID 36049184›Full record

ReviewBiochemistry2023

Recent Advances in Double-Strand Break-Free Kilobase-Scale Genome Editing Technologies.

Connor J Tou, Benjamin P Kleinstiver

Abstract readReview
In one paragraph

Review in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Immune-evasive DNA integration with INSTALL.Nature reviews. Genetics · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Precision Genome Engineering in Human Disease: Expanding Therapeutic Roles of CRISPR Technologies.Nigerian medical journal : journal of the Nigeria Medical Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Connor J TouBiological Engineering Program, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Benjamin P KleinstiverCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.ORCID 0000-0002-5469-0655

Funding

PROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5M
Optimizing Cancer Immunotherapy Safety and Efficacy using Genome EditingR00CA218870 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KLEINSTIVER, BENJAMIN PETER · 2018 to 2020
$730k
NCI NIH HHS R00 CA218870NHLBI NIH HHS P01 HL142494
6 · The paper itself

Abstract

Genome editing approaches have transformed the ability to make user-defined changes to genomes in both

Indexed as

DNA Breaks, Double-StrandedGene EditingCRISPR-Cas SystemsDNA RepairGenomeMutation

Identifiers

PMID36049184
PMCPMC10239562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.