Evidence map›Paper›PMID 36048403›Full record

ArticleJournal of neurovirology2022

Cognitive performance in a South African cohort of people with HIV and comorbid major depressive disorder.

Anna J Dreyer, Sam Nightingale, Lena S Andersen, Jasper S Lee, Hetta Gouse, Steven A Safren, Conall O'Cleirigh, Kevin G F Thomas, John Joska

Open access · greenAbstract read
In one paragraph

Article in Journal of neurovirology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Anna J DreyerDepartment of Psychiatry and Mental Health, HIV Mental Health Research Unit, Neuroscience Institute, University of Cape Town, Cape Town, South Africa. anna.dreyer@uct.ac.za.ORCID 0000-0003-1230-3431
Sam NightingaleDepartment of Psychiatry and Mental Health, HIV Mental Health Research Unit, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Lena S AndersenDepartment of Public Health, Global Health Section, University of Copenhagen, Copenhagen, Denmark.
Jasper S LeeDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Hetta GouseDepartment of Psychiatry and Mental Health, HIV Mental Health Research Unit, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Steven A SafrenDepartment of Psychology, University of Miami, Coral Gables, FL, USA.
Conall O'CleirighDepartment of Psychology, Harvard Medical School, Boston, MA, USA.
Kevin G F ThomasApplied Cognitive Science and Experimental Neuropsychology Team (ACSENT), Department of Psychology, University of Cape Town, Cape Town, South Africa.
John JoskaDepartment of Psychiatry and Mental Health, HIV Mental Health Research Unit, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAHarvard University · USUniversity of Copenhagen · DKUniversity of Miami · US

Funding

The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core & MHD-CEP30MH133399 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI Sannisha K Dale · 2023 to 2026
$8.9M
Nurse-Delivered CBT for Depression-Adherence in HIV Primary Care S. AfricaR01MH103770 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI O'CLEIRIGH, CONALL MICHAEL, SAFREN, STEVEN A · 2015 to 2019
$3.1M
Boston University Medical Campus-Massachusetts General Hospital Global Psychiatric Clinical Research Training ProgramT32MH116140 · NIMH · BOSTON MEDICAL CENTER · PI FRICCHIONE, GREGORY L, HENDERSON, DAVID C · 2018 to 2022
$1.6M
Patient-Oriented Substance Use/Smoking Cessation Research in HIV Treatment and PreventionK24DA062568 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI Conall Michael O'Cleirigh · 2024 to 2026
$639k
NIDA NIH HHS K24 DA062568NIMH NIH HHS P30 MH133399NIMH NIH HHS R01 MH103770NIMH NIH HHS R01MH103770NIMH NIH HHS T32 MH116140
6 · The paper itself

Abstract

Cognitive performance in people with HIV (PWH) may be affected by brain injury attributable to the infection itself, by other medical and psychiatric comorbidities (including major depressive disorder; MDD), and by psychosocial factors (e.g., education, food insecurity). We investigated effects of these variables on cognitive performance in a South African cohort of PWH with comorbid MDD and incomplete adherence to antiretroviral therapy (ART). We also examined (a) associations of depression severity with cognitive performance, and (b) whether improvement in depression led to improved cognitive performance. Participants (N = 105) completed baseline neuropsychological, psychiatric, and sociodemographic assessments. Subsequently, 33 were assigned to a cognitive-behavioural therapy for ART adherence and depression (CBT-AD) and 72 to standard-of-care treatment. Eight months post-baseline, 81 (n

Indexed as

HIV InfectionsMajor Depressive DisorderCognitionDepressionHumansSouth AfricaTreatment OutcomeCognitionDepressionFood insecurityHIVSocioeconomic status

Identifiers

PMID36048403
PMCPMC10471884
OpenAlexW4294123681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.