Evidence map›Paper›PMID 36048309›Full record

ReviewCurrent HIV/AIDS reports2022

Ingestible Electronic Sensors for Monitoring Real-time Adherence to HIV Pre-exposure Prophylaxis and Antiretroviral Therapy.

Georgia R Goodman, Clint Vaz, Hannah Albrechta, Edward W Boyer, Kenneth H Mayer, Conall O'Cleirigh, Peter R Chai

Open access · greenAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Informing Acceptability and Feasibility of Digital Phenotyping for Personalized HIV Prevention among Marginalized Populations Presenting to the Emergency Department.Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences · 2024
    Article
  5. Real-World Implementation Challenges Associated with a Digital Pill System to Measure Adherence to HIV Pre-Exposure Prophylaxis from Two Studies of Men Who Have Sex With Men.Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences · 2024
    Article
  6. Digital therapeutics in the clinic.Bioengineering & translational medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Georgia R GoodmanDepartment of Emergency Medicine, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.
Clint VazDepartment of Emergency Medicine, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.
Hannah AlbrechtaThe Fenway Institute, Fenway Health, Boston, MA, USA.
Edward W BoyerThe Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kenneth H MayerThe Fenway Institute, Fenway Health, Boston, MA, USA.
Conall O'CleirighThe Fenway Institute, Fenway Health, Boston, MA, USA.
Peter R ChaiDepartment of Emergency Medicine, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA. pchai@bwh.harvard.edu.ORCID 0000-0003-0955-4117
Brigham and Women's Hospital · USFenway Health · USBeth Israel Deaconess Medical Center · USThe Ohio State University Wexner Medical Center · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
MyTPill: A Novel Strategy to Monitor Antiretroviral Adherence among HIV+ Prescription Opioid UsersR01DA047236 · NIDA · OHIO STATE UNIVERSITY · PI BOYER, EDWARD W, CARRICO, ADAM WAYNE · 2019 to 2022
$3.0M
Smart Steps: A context-aware adherence intervention to improve PrEP adherence among men who have sex with men (MSM) with substance use disorderDP2DA056107 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHAI, PETER R · 2022 to 2022
$2.7M
Mentoring in Advanced mHealth Technologies and Machine Learning for HIV/Drug Abuse ResearchK24DA037109 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOYER, EDWARD W · 2014 to 2025
$1.9M
A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communitiesR44DA051106 · NIDA · BIOBOT ANALYTICS, INC. · PI CHAI, PETER R, MATUS GARCIA, MARIANA G · 2020 to 2022
$1.5M
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance UsersK23DA044874 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHAI, PETER R · 2018 to 2022
$1.0M
NIDA National Early Warning System Network (iN3): An Innovative ApproachR56DA038366 · NIDA · WRIGHT STATE UNIVERSITY · PI BOYER, EDWARD W, CARLSON, ROBERT GEOFFREY · 2014 to 2014
$300k
ID-Cap System: Next generation ingestible sensors for medication adherence measurementR43NR020289 · NINR · ETECTRX, INC. · PI CARNES, TONY CHRIS, CHAI, PETER R · 2022 to 2022
$259k
NIAID NIH HHS P30 AI060354NIDA NIH HHS DP2 DA056107NIDA NIH HHS K23 DA044874NIDA NIH HHS K24 DA037109NIDA NIH HHS R01 DA047236NIDA NIH HHS R44 DA051106NIDA NIH HHS R56 DA038366NINR NIH HHS R43 NR020289
6 · The paper itself

Abstract

purpose of reviewThis review summarizes the recent advancements and future directions of digital pill systems (DPS) - which utilize ingestible sensors to directly measure medication ingestion events in real-time - in the context of HIV prevention and treatment. RECENT

findingsTwo DPS are cleared by the US Food and Drug Administration. The bioequivalence and stability of digitized pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) have been established, and pilot studies have demonstrated the feasibility and acceptability of using DPS for PrEP and ART adherence measurement. Important bioethical and implementation considerations have been identified for future clinical trials. Continued technological advancement may reduce barriers to use, and integration of DPS into behavioral interventions may facilitate adherence improvement efforts. DPS represent an innovative tool for PrEP and ART adherence measurement. Future work will optimize the technology to reduce operational barriers. DPS have significant potential for expansion across a diverse array of diseases, though key bioethical considerations must be examined prior to large-scale implementation.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisElectronicsHumansMedication AdherenceAnti-HIV AgentsAntiretroviral therapyDigital pill systemIngestible sensorsMedication adherence, Electronic adherencePre-exposure prophylaxis

Identifiers

PMID36048309
PMCPMC9509467
OpenAlexW4294125945

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.