Evidence map›Paper›PMID 36048287›Full record

ArticlePflugers Archiv : European journal of physiology2022

Guanosine modulates K

Giuditta Gambino, Giuseppe Giglia, Daniele Gallo, Miriana Scordino, Costanza Giardina, Mariachiara Zuccarini, Patrizia Di Iorio, Patricia Giuliani, Francisco Ciruela, Giuseppe Ferraro and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Giuditta Gambino *Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy. giuditta.gambino@unipa.it.ORCID 0000-0001-8155-2808
Giuseppe Giglia *Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy.ORCID 0000-0001-5616-3595
Daniele GalloDepartment of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy.ORCID 0000-0001-9565-803X
Miriana ScordinoDepartment of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy.ORCID 0000-0003-4224-5869
Costanza GiardinaDepartment of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy.
Mariachiara ZuccariniDepartment of Medical, Oral and Biotechnological Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.ORCID 0000-0001-8485-9012
Patrizia Di IorioDepartment of Medical, Oral and Biotechnological Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.ORCID 0000-0002-0804-7925
Patricia GiulianiDepartment of Medical, Oral and Biotechnological Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.ORCID 0000-0002-8574-7992
Francisco CiruelaDepartment of Pathology and Experimental Therapeutics, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0003-0832-3739
Giuseppe FerraroDepartment of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy.ORCID 0000-0003-0982-8114
Giuseppa MudòDepartment of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy.ORCID 0000-0002-3275-9981
Pierangelo SardoDepartment of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy.ORCID 0000-0002-4997-3263
Valentina Di LibertoDepartment of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy. valentina.diliberto@unipa.it.ORCID 0000-0002-8574-0061
University of Palermo · ITUniversity of Chieti-Pescara · ITInstitut d'Investigació Biomédica de Bellvitge · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guanosine (GUO), widely considered a key signaling mediator, is implicated in the regulation of several cellular processes. While its interaction with neural membranes has been described, GUO still is an orphan neuromodulator. It has been postulated that GUO may eventually interact with potassium channels and adenosine (ADO) receptors (ARs), both particularly important for the control of cellular excitability. Accordingly, here, we investigated the effects of GUO on the bioelectric activity of human neuroblastoma SH-SY5Y cells by whole-cell patch-clamp recordings. We first explored the contribution of voltage-dependent K

Indexed as

GuanosineNeuroblastomaAdenosineHumansLigandsPotassium ChannelsReceptors, Purinergic P1AdenosineGuanosineLigandsPotassium ChannelsReceptors, Purinergic P1Cellular excitabilityElectrophysiologyPatch-clampPotassium channelsPurinesSH-SY5Y cells

Identifiers

PMID36048287
PMCPMC9560947
OpenAlexW4294127264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.