Evidence map›Paper›PMID 36048214›Full record

ArticleCancer immunology, immunotherapy : CII2023

Compromised activity of natural killer cells in diffuse large b-cell lymphoma is related to lymphoma-induced modification of their surface receptor expression.

Tehila Azoulay, Ilana Slouzky, Michal Karmona, Margarita Filatov, Michal Hayun, Yishai Ofran, Galit Sarig, Shimrit Ringelstein-Harlev

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tehila AzoulayDepartment of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, 8, Ha'Aliya Street, 3109601, Haifa, Israel.
Ilana SlouzkyHematology Laboratory, Rambam Health Care Campus, Haifa, Israel.
Michal KarmonaHematology Laboratory, Rambam Health Care Campus, Haifa, Israel.
Margarita FilatovHematology Laboratory, Rambam Health Care Campus, Haifa, Israel.
Michal HayunDepartment of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, 8, Ha'Aliya Street, 3109601, Haifa, Israel.
Yishai OfranDepartment of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, 8, Ha'Aliya Street, 3109601, Haifa, Israel.
Galit SarigHematology Laboratory, Rambam Health Care Campus, Haifa, Israel. g_sarig@rmc.gov.il.
Shimrit Ringelstein-HarlevDepartment of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, 8, Ha'Aliya Street, 3109601, Haifa, Israel. s_ringelstein@rambam.health.gov.il.ORCID http://orcid.org/0000-0003-4897-1466
Rambam Health Care Campus · ILHebrew University of Jerusalem · ILTechnion – Israel Institute of Technology · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While natural killer (NK) cells are essential players in detection and elimination of malignant cells, these surveillance properties can be compromised by cancer cells. Since NK cell education primarily occurs in the bone marrow and lymphoid tissue, this process might be particularly affected by their infiltration with lymphoma cells. This study aimed to explore functional properties of diffuse large B-cell lymphoma (DLBCL) patient NK cells, which could potentially promote tumour immune evasion and disease propagation.NK cells isolated from the peripheral blood (PB) of 26 DLBCL patients and 13 age-matched healthy controls (HC) were analysed. The cytotoxic CD56

Indexed as

Antineoplastic AgentsLymphoma, Large B-Cell, DiffuseCD56 AntigenHumansKiller Cells, NaturalAntineoplastic AgentsCD56 AntigenCytotoxicityDiffuse large B-cell lymphomaImmune evasionInflammatory cytokinesNatural killer cells

Identifiers

PMID36048214
PMCPMC10992952
OpenAlexW4294012271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.