Evidence map›Paper›PMID 36047999›Full record

ArticleParasite (Paris, France)2022

Enterocytozoon bieneusi in patients with diarrhea and in animals in the northeastern Chinese city of Yichun: genotyping and assessment of potential zoonotic transmission.

Kexin Zhou, Mingchao Liu, Yanchen Wu, Ran Zhang, Ru Wang, Hui Xu, Yujia Wang, Lan Yao, Hongmei Yu, Aiqin Liu

Open access · goldAbstract read
In one paragraph

Article in Parasite (Paris, France), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Molecular epidemiology ofFrontiers in cellular and infection microbiology · 2026
    Article
  2. Article
  3. Molecular Detection ofVeterinary sciences · 2025
    Article
  4. Molecular Detection and Genotyping ofInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Prevalence and Individualized Risk Factors ofJournal of clinical medicine · 2025
    Article
  7. PCR-based detection ofFrontiers in cellular and infection microbiology · 2025
    Article
  8. Article
  9. Brown rats (Frontiers in veterinary science · 2024
    Article
  10. Article
  11. Article
  12. First report on the molecular detection ofInternational journal for parasitology. Parasites and wildlife · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kexin ZhouDepartment of Parasitology, Harbin Medical University, Harbin 150081, Heilongjiang, China.
Mingchao LiuCentral Hospital of Yichun Forestry Administration, Yichun 153000, Heilongjiang, China.
Yanchen WuDepartment of Parasitology, Harbin Medical University, Harbin 150081, Heilongjiang, China.
Ran ZhangCentral Hospital of Yichun Forestry Administration, Yichun 153000, Heilongjiang, China.
Ru WangCentral Hospital of Yichun Forestry Administration, Yichun 153000, Heilongjiang, China.
Hui XuCentral Hospital of Yichun Forestry Administration, Yichun 153000, Heilongjiang, China.
Yujia WangCentral Hospital of Yichun Forestry Administration, Yichun 153000, Heilongjiang, China.
Lan YaoDepartment of Parasitology, Harbin Medical University, Harbin 150081, Heilongjiang, China.
Hongmei YuCentral Hospital of Yichun Forestry Administration, Yichun 153000, Heilongjiang, China.
Aiqin LiuDepartment of Parasitology, Harbin Medical University, Harbin 150081, Heilongjiang, China.
Yichun University · CNHarbin Medical University · CN

Funding

The Yichun Science and Technology Bureau G2019-10
6 · The paper itself

Abstract

Enterocytozoon bieneusi is a common microsporidia species in humans and animals. Due to lack of effective vaccines and drugs, understanding of its epidemiological status and characteristics in different hosts is an important step in controlling the infection. The present study aimed at determining the prevalence of E. bieneusi in humans with diarrhea and animals in Yichun, in northeastern China, and assessing the epidemiological role of animals in the transmission of microsporidiosis. A total of 540 fecal samples were collected from diarrheal patients (n = 222) and 11 animal species (n = 318). Enterocytozoon bieneusi was identified and genotyped by polymerase chain reaction (PCR) and sequencing of the internal transcribed spacer (ITS) region of the rRNA gene. Enterocytozoon bieneusi was detected in 1.4% (3/222) of diarrheal patients, and genotype D and novel genotypes YCHH1 and YCHH2 were identified. Enterocytozoon bieneusi was detected in wild boars (7.7%), sika deer (8.2%), dogs (3.2%), and ostriches (10.7%), and genotypes D, Type IV, Peru6, BEB6 and novel genotypes YCHA1, YCHA2 and YCHA3 were identified. Genotypes YCHH1, YCHH2 and YCHA1 were phylogenetically assigned to group 1, while YCHA2 and YCHA3 to groups 2 and 11, respectively. The finding of genotype D in humans and animals, and the identification of zoonotic genotypes Peru6, Type IV, BEB6 in animal-derived E. bieneusi isolates indicate the potential of zoonotic transmission of microsporidiosis in the investigated area. The observation of the three novel genotypes in group 1 indicates their zoonotic potential.

Indexed as

DeerEnterocytozoonMicrosporidiosisAnimalsChinaDiarrheaDogsFecesGenotypeHumansPhylogenyPrevalenceZoonosesAnimalsDiarrheal patientsEnterocytozoon bieneusiGenotypingITS region

Identifiers

PMID36047999
PMCPMC9435466
OpenAlexW4294122835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.