Evidence map›Paper›PMID 36047984›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis.

Roxana Wasnick, Martina Korfei, Katarzyna Piskulak, Ingrid Henneke, Jochen Wilhelm, Poornima Mahavadi, Ruth Charlotte Dartsch, Daniel von der Beck, Miriam Koch, Irina Shalashova and 16 more

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
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  5. Beyond the epithelium: multicellular niches in lung regeneration and disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  6. Article
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  10. Cellular plasticity and regenerative mechanisms in the lung.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  11. Article
  12. Article
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  14. Review
  15. Mechanisms and markers of lung ageing in health and disease.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  16. Article
  17. Protocol for differentiating primary human small airway epithelial cells at the air-liquid interface.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  18. Review
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 4 countries.

Roxana WasnickUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.ORCID 0000-0003-1114-7799
Martina KorfeiUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Katarzyna PiskulakUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Ingrid HennekeUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Jochen WilhelmUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Poornima MahavadiUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Ruth Charlotte DartschUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Daniel von der BeckUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.ORCID 0000-0003-1946-9303
Miriam KochUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Irina ShalashovaUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Astrid WeissUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Oleksiy KlymenkoUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Ingolf AskevoldDepartment of Surgery, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Ludger FinkInstitut für Pathologie, Überregionale Gemeinschaftspraxis für Pathologie und Zytologie, 35578 Wetzlar, Germany.
Heiko WittPediatric Nutritional Medicine, Else-Kröner-Fresenius-Fresenius-Ceter for Nutritional Sciences, Technical University Munich, 85354 Freising, Germany.
Holger HacksteinDepartment of Clinical Immunology and Transfusion Medicine, Justus-Liebig University Giessen, 35392 Giessen, Germany.
Elie El AghaUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Saverio BellusciUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Walter KlepetkoDepartment of Thoracic Surgery, Vienna General Hospital, 1090 Vienna, Austria.
Melanie KönigshoffComprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Center Munich, Ludwig Maximilians University Munich, 81377 Munich, Germany.ORCID 0000-0001-9414-5128
Oliver EickelbergDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-7170-0360
Ralph Theo SchermulyUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Thomas BraunUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Werner SeegerUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Clemens RuppertUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Andreas GuentherUniversity of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.ORCID 0000-0002-2187-0975
German Center for Lung Research · DEJustus-Liebig-Universität Gießen · DEMax Planck Institute for Heart and Lung Research · DEUniversity of Pittsburgh · USFresenius (Germany) · DEPraxis für Humangenetik · DEVienna General Hospital · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Idiopathic Pulmonary FibrosisPulmonary SurfactantsAlveolar Epithelial CellsAnimalsBleomycinHumansLungMiceReceptor, Notch1Surface-Active AgentsBleomycinNOTCH1 protein, humanPulmonary SurfactantsReceptor, Notch1Surface-Active Agentsdiffuse parenchymal lung diseaseepithelial regenerationidiopathic pulmonary fibrosisinterstitial lung diseaselung surfactant

Identifiers

PMID36047984
OpenAlexW4294125783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.