ArticlePlant physiology2023
Abscisic acid inhibits primary root growth by impairing ABI4-mediated cell cycle and auxin biosynthesis.
Article in Plant physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 57 citations in OpenAlex.
- From activation to desensitization: How ABA balances plant growth and abiotic stress response?Plant communications · 2026Review
- Germination-Related Universal Stress Protein (GRUSP) Is Involved in Abscisic Acid Responses During Imbibition and Early Post-Germination Growth ofInternational journal of molecular sciences · 2026Article
- Integrative transcriptional regulatory networks governing cereal root responses to heavy metals and drought.Plant cell reports · 2026Review
- Article
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- Regulatory effects of mepiquat chloride on soybean yield formation and physiological responses to drought stress.Frontiers in plant science · 2026Article
- Single-nucleus and spatial transcriptomics reveal the cell populations of intercalary meristems in bamboo.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanical contribution of germ cell specification inScience advances · 2025Article
- Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses.Plant communications · 2025Review
- CrWRKY57 and CrABF3 cooperatively activateHorticulture research · 2025Article
- Genome-Wide Identification and Expression Analysis of the GH19 Chitinase Gene Family in Sea Island Cotton.Current issues in molecular biology · 2025Article
- Bamboo Biochar and Sodium Silicate Alleviate Oxybenzone-Induced Phytotoxicity via Distinct Mechanisms for Sustainable Plant Protection.Plants (Basel, Switzerland) · 2025Article
- Copy Number Variation Shapes Structural Genomic Diversity Associated With Ecological Adaptation in the Wild Tomato Solanum chilense.Molecular biology and evolution · 2025Article
- To grow or not to grow: the enigma of plant root growth dynamism.Plant molecular biology · 2025Review
- From Hormones to Harvests: A Pathway to Strengthening Plant Resilience for Achieving Sustainable Development Goals.Plants (Basel, Switzerland) · 2025Review
- Small peptide SiDVL/RTFLs from foxtail millet inhibit root growth through repressing auxin signaling in transgenic Arabidopsis.Plant cell reports · 2024Article
- Efficient In Vitro Regeneration System and Comparative Transcriptome Analysis Offer Insight into the Early Development Characteristics of Explants from Cotyledon with Partial Petiole in Small-Fruited Pepper (International journal of molecular sciences · 2024Article
- Unveiling Molecular Signatures in Light-Induced Seed Germination: Insights from PIN3, PIN7, and AUX1 inPlants (Basel, Switzerland) · 2024Article
- Modulating root system architecture: cross-talk between auxin and phytohormones.Frontiers in plant science · 2024Review
- A Travel through Landscapes of Seed Dormancy.Plants (Basel, Switzerland) · 2023Review
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell cycle progression and the phytohormones auxin and abscisic acid (ABA) play key roles in primary root growth, but how ABA mediates the transcription of cell cycle-related genes and the mechanism of crosstalk between ABA and auxin requires further research. Here, we report that ABA inhibits primary root growth by regulating the ABA INSENSITIVE4 (ABI4)-CYCLIN-DEPENDENT KINASE B2;2 (CDKB2;2)/CYCLIN B1;1 (CYCB1;1) module-mediated cell cycle as well as auxin biosynthesis in Arabidopsis (Arabidopsis thaliana). ABA induced ABI4 transcription in the primary root tip, and the abi4 mutant showed an ABA-insensitive phenotype in primary root growth. Compared with the wild type (WT), the meristem size and cell number of the primary root in abi4 increased in response to ABA. Further, the transcription levels of several cell-cycle positive regulator genes, including CDKB2;2 and CYCB1;1, were upregulated in abi4 primary root tips. Subsequent chromatin immunoprecipitation (ChIP)-seq, ChIP-qPCR, and biochemical analysis revealed that ABI4 repressed the expression of CDKB2;2 and CYCB1;1 by physically interacting with their promoters. Genetic analysis demonstrated that overexpression of CDKB2;2 or CYCB1;1 fully rescued the shorter primary root phenotype of ABI4-overexpression lines, and consistently, abi4/cdkb2;2-cr or abi4/cycb1;1-cr double mutations largely rescued the ABA-insensitive phenotype of abi4 with regard to primary root growth. The expression levels of DR5promoter-GFP and PIN1promoter::PIN1-GFP in abi4 primary root tips were significantly higher than those in WT after ABA treatment, with these changes being consistent with changes in auxin concentration and expression patterns of auxin biosynthesis genes. Taken together, these findings indicated that ABA inhibits primary root growth through ABI4-mediated cell cycle and auxin-related regulatory pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.