Evidence map›Paper›PMID 36047786›Full record

ArticleAntimicrobial agents and chemotherapy2022

Strongly Bactericidal All-Oral β-Lactam Combinations for the Treatment of Mycobacterium abscessus Lung Disease.

Dereje A Negatu, Matthew D Zimmerman, Véronique Dartois, Thomas Dick

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  2. Article
  3. Article
  4. Novel C5α-substituted carbapenems enhanceAntimicrobial agents and chemotherapy · 2025
    Article
  5. Article
  6. Article
  7. Durlobactam in combination with β-lactams to combatAntimicrobial agents and chemotherapy · 2025
    Article
  8. Article
  9. Review
  10. Toward better cures forClinical microbiology reviews · 2024
    Review
  11. Article
  12. Case Commentary: Dual β-lactam as part of regimen to treatAntimicrobial agents and chemotherapy · 2024
    Article
  13. Microbiology spectrum · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Swollen Necrotic Lymphadenitis Infected withInfection and drug resistance · 2024
    Article
  19. TheAntimicrobial agents and chemotherapy · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Dereje A NegatuCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Matthew D ZimmermanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-9470-5009
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-9604-9452
Hackensack Meridian Health · USGeorgetown University · US

Funding

Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
NIAID NIH HHS R01 AI132374
6 · The paper itself

Abstract

Bioactive forms of oral β-lactams were screened

Indexed as

Lung DiseasesMycobacterium abscessusAmoxicillinAnti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsCarbapenemsCefuroximeHumansLactamsMicrobial Sensitivity TestsAmoxicillinAnti-Bacterial AgentsavibactamAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsCarbapenemsCefuroximeLactamssulopenemtebipenemamoxicillinavibactamcefuroximenontuberculous mycobacteriaNTMsulopenemsynergytebipenem

Identifiers

PMID36047786
PMCPMC9487536
OpenAlexW4294018135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.