ArticleJournal of periodontal & implant science2022
Subgingival microbiome in periodontitis and type 2 diabetes mellitus: an exploratory study using metagenomic sequencing.
Article in Journal of periodontal & implant science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 15 citations in OpenAlex.
- The synergistic pro-inflammatory effect of butyric and propionic acid on human periodontal ligament cells via activation of G-protein-coupled receptor 41.Journal of periodontal & implant science · 2026Article
- Metagenomic insights into oral microbiota dynamics in diabetic and non-diabetic periodontal disease: a pilot study.Frontiers in microbiology · 2026Article
- The subgingival microbiome in periodontitis: from ecological dysbiosis and metabolic reprogramming to precision interventions.Frontiers in microbiology · 2026Review
- Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Mannose phosphotransferase system subunit IID of Streptococcus mutans elicits maturation and activation of dendritic cells.Journal of microbiology (Seoul, Korea) · 2025Article
- Metabolic Reprogramming in Respiratory Viral Infections: A Focus on SARS-CoV-2, Influenza, and Respiratory Syncytial Virus.Biomolecules · 2025Review
- Analysis of the diversity and function of the microbiota in infected root canals of type 2 diabetes mellitus with apical periodontitis.Frontiers in cellular and infection microbiology · 2025Article
- Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential.Journal of translational medicine · 2024Review
- Clinical attachment loss is cross-sectionally associated with elevated glucose among adults without diabetes.Journal of clinical periodontology · 2024Article
- Exploration of the relationship between periodontal disease and skin disease in honor of Gum Day.Journal of periodontal & implant science · 2023Article
- The Bidirectional Relationship between Periodontal Disease and Diabetes Mellitus-A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Combining Semi-Targeted Metabolomics and Machine Learning to Identify Metabolic Alterations in the Serum and Urine of Hospitalized Patients with COVID-19.Biomolecules · 2023Article
- The interplay between gingival crevicular fluid microbiome and metabolomic profile in intensively treated people with type 1 diabetes - a combined metagenomic/metabolomic approach cross-sectional study.Frontiers in endocrinology · 2023Article
- Current scientific evidence for why periodontitis should be included in diabetes management.Frontiers in clinical diabetes and healthcare · 2023Article
- Diabetes mellitus promotes susceptibility to periodontitis-novel insight into the molecular mechanisms.Frontiers in endocrinology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo explore differences in the subgingival microbiome according to the presence of periodontitis and/or type 2 diabetes mellitus (T2D), a metagenomic sequencing analysis of the subgingival microbiome was performed.
methodsTwelve participants were divided into 4 groups based on their health conditions (periodontitis, T2D, T2D complicated with periodontitis, and generally healthy). Subgingival plaque was collected for metagenomic sequencing, and gingival crevicular fluids were collected to analyze the concentrations of short-chain fatty acids.
resultsThe shifts in the subgingival flora from the healthy to periodontitis states were less prominent in T2D subjects than in subjects without T2D. The pentose and glucuronate interconversion, fructose and mannose metabolism, and galactose metabolism pathways were enriched in the periodontitis state, while the phosphotransferase system, lipopolysaccharide (LPS) and peptidoglycan biosynthesis, bacterial secretion system, sulfur metabolism, and glycolysis pathways were enriched in the T2D state. Multiple genes whose expression was upregulated from the red and orange complex bacterial genomes were associated with bacterial biofilm formation and pathogenicity. The concentrations of propionic acid and butyric acid were significantly higher in subjects with periodontitis, with or without T2D, than in healthy subjects.
conclusionsT2D patients are more susceptible to the presence of periodontal pathogens and have a higher risk of developing periodontitis. The pentose and glucuronate interconversion, fructose and mannose metabolism, galactose metabolism, and glycolysis pathways may represent the potential microbial functional association between periodontitis and T2D, and butyric acid may play an important role in the interaction between these 2 diseases. The enrichment of the LPS and peptidoglycan biosynthesis, bacterial secretion system, and sulfur metabolism pathways may cause T2D patients to be more susceptible to periodontitis.
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