ArticlePediatrics2022
Lesion-Specific Congenital Heart Disease Mortality Trends in Children: 1999 to 2017.
Article in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Impact of Subspecialty Pediatric Palliative Care on Children with Heart Disease; A Systematic Review and Meta-analysis.Pediatric cardiology · 2025Pooled it
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- Linking shape and clinical outcomes: Statistical shape model of Bidirectional Glenn connection in congenital single ventricle patients.PLOS digital health · 2026Article
- Comparison of a Cardiac Specific Versus a General Instrument to Assess Health-Related Quality of Life 4-5 Years After Cardiac Surgery in Early Infancy.CJC pediatric and congenital heart disease · 2026Article
- Congenital heart disease in children in Hawassa, Ethiopia: a multicenter study on patterns, complications, survival, and mortality predictors.BMC cardiovascular disorders · 2026Article
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- Treatment Options Offered to Infants with Single Ventricle Physiology and Genetic Aneuploidy: A Survey of US Pediatric Intensivists, Cardiologists, and Cardiothoracic Surgeons.Pediatric cardiology · 2026Article
- Congenital Heart Defects and Concurrent Diagnoses in Influenza Hospitalization in the Pediatric Health Information System Study, 2004-2019.Pediatric cardiology · 2025Article
- Gremlin1 repression-mediated mitochondrial network hyperfunction contributes to TCE-induced zebrafish cardiac defects.Cell communication and signaling : CCS · 2025Article
- Nomogram for prediction of in-hospital mortality rate in children with congenital heart disease in pediatric intensive care: establishment and external validation.Translational pediatrics · 2025Article
- Development and validation of a prognostic risk model for pediatric patients with left-to-right shunt congenital heart disease and heart failure.Frontiers in public health · 2025Article
- Evaluating the global, regional, and national burden of congenital heart disease in infants younger than 1 year: a 1990-2021 systematic analysis for the GBD study 2021.Frontiers in pediatrics · 2025Article
- Enhancing the Classification of Congenital Heart Defects for Outcome Association Studies in Birth Defects Registries.Birth defects research · 2024Article
- Human Milk Feeding and Direct Breastfeeding Improve Outcomes for Infants With Single Ventricle Congenital Heart Disease: Propensity Score-Matched Analysis of the NPC-QIC Registry.Journal of the American Heart Association · 2023Article
- Article
- Survival From Birth Until Young Adulthood Among Individuals With Congenital Heart Defects: CH STRONG.Circulation · 2023Article
- Analysis of theTranslational pediatrics · 2023Article
- Human milk feeding and direct breastfeeding improve outcomes for infants with single ventricle congenital heart disease: Propensity score matched analysis of the NPC-QIC registry.medRxiv : the preprint server for health sciences · 2023Article
- Survival and Risk Factors for Mortality in Infants With Congenital Heart Disease in South Korea.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveCongenital heart disease (CHD) is a leading cause of premature death in infants and children. Currently limited data are available regarding lesion specific mortality over time. Our study aimed to describe pediatric mortality trends by CHD lesion in the United States.
methodsWe conducted a 19 year analysis (1999 to 2017) of publicly available, deidentified multiple cause of death data compiled and produced by the National Center for Health Statistics. Analysis was stratified by CHD diagnosis and age using 3 age categories (infants, 1 to 4 years, and 5 to 17 years). Temporal trends of CHD mortality and the effect of contributing risk factors were analyzed by using joinpoint regression.
resultsMortality was highest for in infants for all CHD lesions, in particular for total anomalous pulmonary venous return. Significant declines in infant CHD mortality occurred for most other lesions. Contributing risk factors, including prematurity, extracardiac birth defects, and genetic conditions, occurred in 19% of infant CHD deaths and demonstrated worse mortality trends in the majority of lesions. Mortality rates remained highest for single ventricle lesions in all ages, with an infant mortality rate plateau in the later half of the study and progressive increasing mortality rates for children 5 to 17 years.
conclusionsCHD mortality is decreasing for most lesions. Because of the heterogenicity of CHD lesions, there is expected variability in mortality trends by lesion and age group. Single ventricle lesions continue to contribute most heavily to premature death because of CHD demonstrated by significant increases in mortality rate for children aged 5 to 17 years.
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