Evidence map›Paper›PMID 36047012›Full record

ArticleDrug delivery2022

Repurposing levocetirizine hydrochloride loaded into cationic ceramide/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization,

Rofida Albash, Rania Moataz El-Dahmy, Mohammed I A Hamed, Khaled M Darwish, Abdulrahman M Alahdal, Amira B Kassem, Abdurrahman M Fahmy

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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  10. Formulation optimization,Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 2 countries.

Rofida AlbashDepartment of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt.
Rania Moataz El-DahmyDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Cairo, Egypt.
Mohammed I A HamedDepartment of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Faiyum, Egypt.
Khaled M DarwishDepartment of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Abdulrahman M AlahdalDepartment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Amira B KassemDepartment of Clinical Pharmacy and Pharmacy Practice Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.
Abdurrahman M FahmyDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Giza, Egypt.
Cairo University · EGDamanhour University · EGFayoum University · EGKing Abdulaziz University · SAMisr University for Science and Technology · EGOctober 6 University · EGSuez Canal University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levocetirizine hydrochloride (LVC) is an antihistaminic drug that is repurposed for the treatment of alopecia. This investigation is targeted for formulating LVC into cationic ceramide/phospholipid composite (CCPCs) for the management of alopecia. CCPCs were fabricated by ethanol-injection approach, through a central composite experiment. CCPCs were evaluated by inspecting their entrapment efficiency (EE%), polydispersity index (PDI), particle size (PS), and zeta potential (ZP). The optimum CCPCs were additionally studied by

Indexed as

CeramidesPhospholipidsAlopeciaCetirizineDrug CarriersDrug RepositioningHumansParticle SizeCeramidesCetirizineDrug CarrierslevocetirizinePhospholipidsAlopeciaceramidedrug discoveryindustrial developmentin-silico studylevocetirizine hydrochloride

Identifiers

PMID36047012
PMCPMC9448385
OpenAlexW4294031588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.